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Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences.

Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease.

• Organized by disease orientation for ease of...

• This series provides a forum for discussion of new discoveries, approaches, and ideas
• Contributions from leading scholars and industry experts
• Reference guide for researchers involved in molecular biology and related fields

We are now on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The recognition, for example, that mutant proteins are frequently misrouted molecules, rather than functionally defective ones, changes our approach to "inborn errors of metabolism" and offers new approaches for pharmacological discovery, based on rescue of receptors, ion channels and enzymes with pharmacoperones. Ion channels, regulators of G-protein signaling and enzymes engaged in regulation, now present opportunities for drug...

Continuing progress has been made in understanding the brain at the molecular, anatomic, and physiological levels in the years following the "Decade of the Brain," with the results providing insight into the underlying basis of many neurological disease processes. In Neuroscience in Medicine, Third Edition, a distinguished panel of basic and clinical investigators, noted for their teaching excellence, provide thoroughly updated and revised chapters to reflect these remarkable advances. Designed specifically for medical students and allied health professionals, this up-to-date edition...

The discovery of catalytic RNAs in the mid-1980s marked the beginning of a new era in RNA biology and an ever increasing appreciation of the diverse and critical roles played by this fascinating molecule. In" ""Recombinant and In Vitro RNA Synthesis: Methods and Protocols," expert researchers in the field detail approaches from the inception of a new RNA project to the final sample ready for analysis. These experimental protocols combine established work-horse approaches with some of the latest innovative methods for RNA synthesis and purification. Written in the highly successful "Methods...

This volume of Methods in Enzymology is the third of 3 parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike.

• The third of 3 parts looking at current methodology for the imaging and spectroscopic analysis of live cells
• The chapters provide hints and tricks not available in primary research publications
• It is an invaluable resource for academics, researchers...

Cell biology spans among the widest diversity of methods in the biological sciences. From physical chemistry to microscopy, cells have given up with secrets only when the questions are asked in the right way This new volume of Methods in Cell Biology covers laboratory methods in cell biology, and includes methods that are among the most important and elucidating in the discipline, such as bioluminescent imaging of gene expressions, confocal imaging, and electron microscopy of bone.

• Covers the most important laboratory methods in cell biology
• Chapters...

As fast-paced technical changes are transforming the field of information science, this book explores in depth the early stages of the field through the history of the American Society for Information Science (ASIS), which began in 1937 as the American Documentation Institute (ADI). ADIs early years coincided with the period when the organization, communication, and retrieval of information began to undergo critical changes. At this time, its appointed members represented the scientific and scholarly elite of the country. ADI offered innovative services that allowed research workers to...