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Psychotic disorders such as schizophrenia and bipolar disorder are known to be highly heritable. Despite decades of research, however, the genetic variations conferring susceptibility to these illnesses have yet to be identified. Such genetic variations most likely produce abnormalities of brain structure and function from which the clinical features of psychosis emerge.

The Maudsley Family Study of Psychosis investigates the genetically produced markers of abnormal brain structure and function ( intermediate phenotypes ) which underlie the clinical syndrome of schizophrenia, and more...

In this book, novelist Colm Toibin offers a deeply personal introduction to the work and life of one of his most important literary influences--the American poet Elizabeth Bishop. Ranging across her poetry, prose, letters, and biography, Toibin creates a vivid picture of Bishop while also revealing how her work has helped shape his sensibility as a novelist and how her experiences of loss and exile resonate with his own. What emerges is a compelling double portrait that will intrigue readers interested in both Bishop and Toibin.

For Toibin, the secret of Bishop's emotional power is...

Mathematical card effects offer both beginning and experienced magicians an opportunity to entertain with a minimum of props. Featuring mostly original creations, Mathematical Card Magic: Fifty-Two New Effects presents an entertaining look at new mathematically based card tricks.

Each chapter contains four card effects, generally starting with simple applications of a particular mathematical principle and ending with more complex ones. Practice a handful of the introductory effects and, in no time, you ll establish your reputation as a "mathemagician."...

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of...

Toibin examines the life and work of some of the greatest and most influential writers of the past two centuries, figures whose homosexuality remained hidden or oblique for much of their lives, either by choice or necessity. The larger world couldn't know about their sexuality, but in their private lives, and in the...

Novelist and critic Colm Toibin explores the relationships of writers with their families and their work in the brilliant, nuanced, and wholly original New Ways to Kill Your Mother.

Toibin--celebrated both for his...