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Solving modern biological problems requires advanced computational methods. Bioinformatics evolved from the active interaction of two fast-developing disciplines, biology and information technology. The central issue of this emerging field is the transformation of often distributed and unstructured biological data into meaningful information.

This book describes the application of well-established concepts and techniques from areas like data mining, machine learning, database technologies, and visualization techniques to problems like protein data analysis, genome analysis and...

Genetic algorithms (GAs) are powerful search techniques based on principles of evolution and widely applied to solve problems in many disciplines. However, most GAs employed in practice nowadays are unable to learn genetic linkage and suffer from the linkage problem. The linkage learning genetic algorithm (LLGA) was proposed to tackle the linkage problem with several specially designed mechanisms. While the LLGA performs much better on badly scaled problems than simple GAs, it does not work well on uniformly scaled problems as other competent GAs. Therefore, we need to understand why it is...

Genetic algorithms (GAs) are powerful search techniques based on principles of evolution and widely applied to solve problems in many disciplines. However, most GAs employed in practice nowadays are unable to learn genetic linkage and suffer from the linkage problem. The linkage learning genetic algorithm (LLGA) was proposed to tackle the linkage problem with several specially designed mechanisms. While the LLGA performs much better on badly scaled problems than simple GAs, it does not work well on uniformly scaled problems as other competent GAs. Therefore, we need to understand why it is...

In recent years, the issue of linkage in GEAs has garnered greater attention and recognition from researchers. Conventional approaches that rely much on ad hoc tweaking of parameters to control the search by balancing the level of exploitation and exploration are grossly inadequate. As shown in the work reported here, such parameters tweaking based approaches have their limits; they can be easily "fooled" by cases of triviality or peculiarity of the class of problems that the algorithms are designed to handle. Furthermore, these approaches are usually blind to the interactions between the...

Solving modern biological problems requires advanced computational methods. Bioinformatics evolved from the active interaction of two fast-developing disciplines, biology and information technology. The central issue of this emerging field is the transformation of often distributed and unstructured biological data into meaningful information.

This book describes the application of well-established concepts and techniques from areas like data mining, machine learning, database technologies, and visualization techniques to problems like protein data analysis, genome analysis and...

The Principle of Large Numbers indicates that macro fluctuations have weak microfoundations; persistent business cycles and interrupted technologies can be better characterized by macro vitality and meso foundations. Economic growth is limited by market extent and ecological constraints. The trade-off between stability and complexity is the foundation of cultural diversity and mixed economies. The new science of complexity sheds light on the sources of economic instability and complexity.

This book consists of the major work of Professor Ping Chen, a pioneer in studying economic chaos...