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Three members of the genus Yersinia are important human pathogens, causing diseases ranging from the deadly Plague (Yersinia pestis) to a relatively mild gastroenteritis (Y. enterocolitica and Y. pseudotuberculosis). Plague, a re-emerging disease, is endemic in many parts of the world. The extraordinary pathogenicity of Y. pestis makes it a potential bioterrorist weapon. On the other hand, the two enteropathogenic Yersinia species represent the third most common bacterial cause of gastroenteritis in Europe and probably elsewhere, although their prevalence is largely underestimated. This, and...

Written by the top Yersinia specialists, the book reviews the molecular biology of these important organisms and comprehensively covers recent advances in the field. Topics include genetic diversity in Y. pestis, quorum sensing, identification of virulence genes, regulation of virulence elements, superantigens, host invasion, host immune response, LPS structure and genetics, flagellar-dependent motility, flagellar-dependent protein secretion, iron or heme transport systems, Yersinia pathogenicity Islands, the Yop effector proteins, plasminogen activator (Pla), F1 antigen, and the conjugative...