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There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.

TRENDS IN LINGUISTICS is a series of books that open new perspectives in our understanding of language. The series publishes state-of-the-art work on core areas of linguistics across theoretical frameworks as well as studies that provide new insights by building bridges to neighbouring fields such as neuroscience and cognitive science.

TRENDS IN LINGUISTICS considers itself a forum for cutting-edge research based on solid empirical data on language in its various manifestations, including sign languages. It regards linguistic variation in its synchronic and diachronic dimensions as...

Adaptive Designs for Sequential Treatment Allocation presents a rigorous theoretical treatment of the results and mathematical foundation of adaptive design theory. The book focuses on designing sequential randomized experiments to compare two or more treatments incorporating information accrued along the way.

The authors first introduce the terminology and statistical models most commonly used in comparative experiments. They then illustrate biased coin and urn designs that only take into account past treatment allocations as well as designs that use past...

This monograph shows that, through a recourse to the concepts and methods of abstract algebraic logic, the algebraic theory of regular varieties and the concept of analyticity in formal logic can profitably interact. By extending the technique of Plonka sums from algebras to logical matrices, the authors investigate the different classes of models for logics of variable inclusion and they shed new light into their formal properties.

The book opens with the historical origins of logics of variable inclusion and on their philosophical motivations. It includes the basics of the...

This monograph shows that, through a recourse to the concepts and methods of abstract algebraic logic, the algebraic theory of regular varieties and the concept of analyticity in formal logic can profitably interact. By extending the technique of Plonka sums from algebras to logical matrices, the authors investigate the different classes of models for logics of variable inclusion and they shed new light into their formal properties.

The book opens with the historical origins of logics of variable inclusion and on their philosophical motivations. It includes the basics of the...