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This volume describes the pathogenesis and pathophysiology of several pulmonary diseases as well as their treatment. It also discusses the underlying genetic and molecular biological basis, which opens the way for new treatments for these conditions.

It focuses on the treatment of cystic fibrosis including CFTR (cystic fibrosis transmembrane-conductance regulator) modulator therapies, drug therapies that augment airway surface liquid as well as anti-inflammatory and anti-infective therapies. Further topics include long-term, low-dose macrolide therapy for diffuse panbronchiolitis;...

Taurine (2-aminoethanesulfonic acid) is an enigmatic compound abounding in animal tissues. It is present at relatively high concentrations in all electrically excitable tissues such as brain, sensory organs, heart, and muscle, and in certain endocrine glands. Some of its physiological functions are already established, for example as an essential nutrient during development and as a neuromodulator or osmolyte, but the cellular mechanisms are still mostly a matter of conjecture. Moreover, there are a number of other putative functions of taurine less well known at present.

In recent times, the Asia-Pacific region has far surpassed Europe in terms of reciprocal trade with the United States, and since the 1980s immigrants from Asia entering the United States have exceeded their counterparts from Europe, reversing a longstanding historical trend and making Asian Americans the country's fastest growing racial group. What does transpacific history look like if the arc of the story is extended to the present?

The essays in this volume offer answers to this question challenging current assumptions about transpacific relations. Many of these assumptions are...