Study of Ondansetron with SSRI's in Some Animal Models of Depression

ISBN-13: 9783659001635 / Angielski / Miękka / 2012 / 112 str.

Anuradha Chivate; Niranjan Chivate

Opis

By the year 2020, depression will be the second leading cause of death. So it should be treated carefully. Classically, Tricyclic antidepressants and Monoamine oxidase Inhibitors were used to treat depression. But recently, clinically effective antidepressants with rapid onset of action and less side effects are developed. Here, selective serotonin reuptake inhibitors like fluoxetine, escitalopram are used in combination with ondansetron.Ondansetron may directly block 5HT3 receptors which modulate neuronal release of other neurotransmitters like Nor-epinephrine which is the possible mechanism of action. And also SSRIs are having gastrointestinal side effects which can be inhibited by ondansetron & also show additive antidepressant effect. In present study, an attempt was made to find out which is the best combination for antidepressant treatment between different doses of ondansetron and SSRIs.

O autorze

Mrs. Anuradha Chivate has obtained her Master s degree in Pharmacology in year 2011 with first class. Since then she has been working as an Assistant Professor in Government College of Pharmacy,Karad. She has experience of six years in production and marketing.She has published one review article and two research papers in various reputed journals.