Current Therapy in Nephrology: Proceedings of the 2nd International Meeting on Current Therapy in Nephrology Sorrento, Italy, May 22-25, 1988

ISBN-13: 9781461282099 / Angielski / Miękka / 2011 / 608 str.

Antonia Dal Canton; Vittorio E. Andreucci; Vittorio E. Andreucci

Opis

This book includes the proceedings of the 2nd International Meeting on Cur rent Therapy in Nephrology held in Sorrento, Italy, May 22-25, 1988. The book provides a comprehensive update on new therapeutic strategies in the broad field of Nephrology. The reader will receive information on advances in treatment of glomerulonephritis, new dialysis techniques and progress in renal transplantation. In addition, sections deal with provocative experimental ap proaches to treating renal disease. Topics include: cyclosporine in treatment of nephrotic syndrome, plasma ex change in ARF, treatment of beta-2 microglobulin amyloidosis, nutritional of dialytic adequacy revisited after assessment in patients on RDT, standards development of biocompatible membranes, drug interaction with cyclosporine, renal transplantation in elderly recipients, and renal transplantation with elderly donors. A special effort was made to recruit contributors among the most important scientific authorities in their respective fields: we are grateful to Drs. Cameron, Lamm, Isemberg, Meyrier, Niaudet, Brynger, Lundgren, Fauchald, Cockburn, Gotch, Kopple, Cheung and Horl for having accepted our invitation. We are also indebted to all other authors who participated in the meeting and submitted their original papers for publication. I.

Spis treści

I. Glomerular Diseases.- Therapy of Nephritis: New Strategies.- Cell mediated immunity in glomerulonephritis: prospects for treatment.- Enzyme therapy of experimental glomerulonephritis.- DNA antibodies and idiotypes.- Reduction of protein excretion by allopurinol in rats with adriamycin nephrosis.- Clinical experience with an antithrombotic agent (defibrotide) in glomerular diseases. Preliminary results.- Defibrination with ancrod in crescentic glomerular lesions: preliminary observation.- PAF induced glomerular and vascular alterations in the isolated perfused rat kidney.- Histogenesis of glomerular crescents in idiopathic proliferative extracapillary glomerulonephritis. Clinical Aspects.- Premises for an antioxidant therapy in pregnancy induced nephropathy.- Pulse therapy with cyclophosphamide in primary and systemic glomerulopathy resistant to steroid treatment.- IgA Nephropathy.- Clinical presentation of IgA nephropathy in southern Italy.- Interleukin-2 production and abnormalities of immune regulation in patients with primary IgA nephropathy.- In vitro study of T lymphocyte activation in IgA nephropathy.- HLA class II histoglobulins involvement in mesangial IgA glomerulonephritis (Berger’s disease).- Variation in T lymphocyte subsets in IgA nephropathy.- Acute renal failure as expression of IgA nephropathy.- Abnormal intestinal permeability in IgA nephropathy.- Nephrotic Syndrome.- Efficiency and tolerance of cyclosporine treatment in adult nephrosis.- Cyclosporine treatment of childhood idiopathic nephrosis.- Acute renal effects of intravenous high dose methylprednisolone therapy in nephrotic syndromes.- Should steroid therapy be used in nephrotic syndrome related to hepatitis B virus associated nephritis?.- Cyclosporine A therapy in nephrotic adults.- Cyclosporine effect on corticoresistant nephrotic syndrome in primary glomerulonephritis.- Effects of Cyclosporine A on renal function and proteinuria in patients with nephrotic syndrome after a single oral administration.- Cyclosporine A therapy in idiopathic nephrotic syndrome.- Captopril as an antiproteinuric agent in patients with chronic glomerulonephritis.- Steroid-resistant nephrotic syndrome treated with Cyclosporine A.- Miscellany.- Intravascular volume expansion as therapeutic approach to the underfill state of pre-eclampsia.- A prospective randomized therapeutic trial for schistosomal specific nephropathy.- Immunotactoid glomerulopathy: what about therapy?.- Renal presentation is not a relevant factor in predicting renal outcome in patients with systemic lupus.- Is tubulointerstitial damage a reliable index for predicting renal outcome in primary membranous nephropathy?.- Serum IgA in children with acute post-infectious glomerulonephritis.- Epidemiology of idiopathic glomerular disease in a french area: a prospective study.- II. Therapy in Renal Failure.- Plasma Exchange in Acute Renal Failure.- Clinical course of rapidly progressive glomerulonephritis during immunosuppressive therapy, plasma exchange and without specific therapy.- Plasma exchange in treatment of acute vascular rejection.- Evaluation of plasma exchange effect in patients with lung hemorrhage and rapidly progressive glomerulonephritis either idiopathic or vasculitis associated.- Current treatment of acute renal failure from leptospirosis.- Plasma exchange induced improvement on extra-renal manifestations of systemic lupus erithematosus.- Medical Therapy in Chronic Renal Failure.- Feasibility of an integrated diet-dialysis program as a treatment of ESRD.- Treatment of uremic anemia with etretinate: comparison with recombinant human erythropoietin.- Acute effects of carnitine addition to the dialysis fluid during hemodialysis in patients with chronic renal failure.- Clonidine is effective in the treatment of “restless legs” syndrome in chronic uremic patients.- Hemorheology and hypertension in end-stage renal failure patients treated with erythropoietin.- Effects of chronic hyperproteic diet on renal function and albumin excretion.- ACE inhibition and progression of renal injury in man.- One year experience with hypoproteic diet and once a week hemodialysis (less than 5 hours).- Calcitriol and renal failure.- Torasemide, a loop diuretic, useful in correcting ECF volume expansion in patients with chronic renal failure.- Miscellany.- Treatment of rapidly progressive lupus glomerulonephritis.- The effect of a single perinatal treatment with captopril on cytotoxicity in rats.- New evidence for the neurotoxicity of PTH in uremia.- Connection between chronic renal insufficiency and alluvial soils in central Greece.- III. Dialysis.- New Techniques.- Clearances of small solutes in hemodiafiltration and paired filtration dialysis.- L-carnitine addition in the dialysis fluid: a new therapeutical approach for hemodialysis patients.- Bidirectional bloodpump with a bidirectional bloodpassage through the artificial kidney.- Hemodialysis with low flow of sterile dialysate. Experience of two years.- Continuous veno-venous hemofiltration for hemodynamic stabilisation by blood cooling in septic shock.- Blood volume changes during hemodialysis detected by conductivity measurements.- A new hemodialysis single patient unit in the short dialysis treatments.- Paired filtration dialysis: better purification than conventional hemodialysis.- Modification of biohumoral and electromyographic features in patients on PFD: 12 months follow up results.- Restoration of the strength of ESRF patients by PFD.- Beta-2-Microglobulin.- Relation between red blood cell function and beta-2 microglobulin concentration in hemodialysis.- Beta-2-microglobulin adsorption on activated charcoal.- Clinical characteristics of beta-2-microglobulin associated amyloidosis in chronic haemodialysis patients.- Plasma beta-2-microglobulin changes induced by different dialysis membranes.- Intradialytic behaviour of beta-2-microglobulin during acetate dialysis, biofiltration and paired filtration dialysis.- In vitro influence of six dialysis membranes on beta-2-microglobulin behaviour.- Behaviour of beta-2-microglobulin in CRF patients starting blood purification.- Nutrition.- Standards for nutritional assessment in dialysis.- Is malnutrition a clinically evident condition in patients undergoing hemodialysis?.- Serum branch-chain amino- and ketoacids in the nutritional and immunological assessment of uremics on conservative and dialysis treatment.- Nutritional abnormalities as a guide to prognosis in hemodialyzed patients.- Relationship between physical activity and nutritional status in patients on maintenance hemodialysis.- Risk factors of malnutrition in RDT patients.- Dietetic supplements in malnourished patients undergoing chronic hemodialysis.- Biocompatibility.- Clinical aspects of hemodialysis biocompatibility.- Cellular aspects of biocompatibility.- Hemodialysis-associated neutrophil abnormalities and generation of leukotriene B4.- An immunohistochemical technique for the study of plasma proteins absorbed on dialysis membranes.- Adsorption of anaphylatoxins C3a and C5a on AN-69 and polysulfone membranes of dialyzer-In vivo study.- Blood cooling prevents degranulation of neutrophils during hemodialysis.- Long term effects of blood-material interactions.- Blood concentration of plasticizer at steady-state in dialysing patients: A model.- IgE ethylene antioxide and eosinophilia dialysis.- Criteria of Adequacy.- Criteria for adequate hemodialysis.- Dialytic adequacy of different replacement treatments.- Routine evaluation of kt/V and protein catabolic rate.- Adequacy of biofiltration: A comparative study with standard acetate hemodialysis.- Is it possible a mathematical verification of Kt/V?.- Adequacy of dialysis and prolonged reuse.- Acid-Base Balance.- Positive acid balance in patients undergoing chronic hemofiltration.- Trends of BUN and acid-base status during high efficiency hemodialysis.- Clinical results of acetate free biofiltration. Two years experience.- Successful treatment with bicarbonate dialysis of severe lactic acidosis in phenformin treated patients on dialytic treatment.- Metabolic assessment of acetate-free biofiltration.- Bicarbonate and calcium balance in postdilutional hemodiafiltration.- Vascular Access.- Intra-arterial digital subtraction angiography for evaluation of AV-fistulas in hemodialysis patients.- Miscellany.- Oxalate clearance by high-flux haemodialysis using polyacrylonitrile membranes.- Technical and clinical evaluation of a new low flux polysulphon membrane.- Ultrafiltration control in short time dialysis.- Red cell fragmentation syndrome in chronic single needle dialysis.- Hypotension and cardiac arrhythmias: A consequence of left ventricular hypertrophy in dialysis.- One-year experience with short dialysis using a high efficiency dialyzer.- The influence of nifedipine on serum lipids in elderly chronic dialysis patients.- Effect of dialysate calcium concentration changes on plasma calcium and PTH in dialysis patients treated with calcium carbonate as a phosphate binder.- Cerebral atrophy in long-term haemodialyzed patients.- Beneficial effect of desferrioxamine on the anaemia of a haemodialysis patient without aluminium or iron overload.- Transient erythrocyte volume increase in hemodialysis.- Assessment of liver ability to biotransformation of antipyrine in uraemic patients on regular peritoneal dialysis treatment.- Clinical pitfalls of short-term dialysis.- Pharmacokinetics of chlordesmethyldiazepam in patients on regular hemodialysis.- Effect of polyacrylonitrile membrane upon plasma osteocalcin and iPTH levels in patients on maintenance hemodialysis.- Abdominal hernias as complication of C.A.P.D.: Importance of the early diagnosis and surgery.- Hemodialysis in the elderly.- IV. Transplantation.- Age and Renal Transplantation.- Age and renal transplantation.- Influence of recipient age on the outcome of cadaver kidney transplantation in patients treated with cyclosporine.- Renal replacement therapy in patients over 60 years of age and the use of elderly living donors.- Impact of donor age in relation with graft survival and quality of remaining kidney of donor.- Is age over 55 years risk factor for kidney donor and for graft function in living related renal transplantation?.- Renal transplantation in patients aged over 50 years.- Kidney transplantation at an advanced age.- Cadaveric renal tranplantation in the elderly.- Renal transplantation in elderly recipients.- Renal transplantation with elderly donor.- Miscellany.- Calcium antagonists prevent lymphocyte activation in kidney allograft recipients.- A prospective randomized study of the protective effect of verapamil on the ischaemic renal injury in renal allotransplants.- Effects of systemic administration of the PGE-1 analogue alprostadil in the early phase of renal transplantation.- Interleukin-2 production by peripheral blood lymphocytes in the diagnosis of renal allograft rejection in cyclosporin treated patients.- Changes of anti-thrombin III, protein C, and protein S in renal transplantation.- Kaposi’s sarcoma after kidney transplantation, an etiologic study and successful treatment.- Renal arterial stenosis in renal transplantation: A mathematical pathogenetic hypothesis and its possible clinical implications.- “Renal functional reserve” in renal transplant patients on cyclosporine therapy.- V. Cyclosporine.- Drug Interactions.- Sandimmun(r) /An appraisal of drug interactions.- Drug interaction between cyclosporin A and macrolides antibiotics: Study in vitro and in vivo.- Interaction of calcium antagonists and cyclosporine A.- Cyclosporine and H2 receptor antagonists drug interaction in the Sprague-Dawley rat.- Cyclosporine A drug interactions.- Cyclosporine A and glybenclamide. Effect on glucose metabolism: Preliminary results.- Side Effects.- Acute cyclosporine A nephrotoxicity.- Renal pathology after low dose cyclosporine in patients with primary Sjogren’s syndrome.- The influence of cyclosporine on cytomegalovirus-related kidney graft survival.- Kaposi’s sarcoma in kidney graft recipients treated with low doses of cyclosporine.- A cellular mechanism for cyclosporine A-induced nephrotoxicity.- Dopamine reverses acute cyclosporine A nephrotoxicity. Micropuncture study in the rat.- Reversibility of acute cyclosporine renal impairment by dopamine in healthy subjects.- Relation between gengival overgrowth and cyclosporine blood levels in renal transplanted patients.- Author Index.