Molecular Insight into Human Platelet Antigen HPA-1 Polymorphism » książka
Molecular Insight into Human Platelet Antigen HPA-1 Polymorphism
ISBN-13: 9783659444111 / Angielski / Miękka / 2013 / 288 str.
Human platelet HPA-1 polymorphism is embedded in the N-terminal plexin/semaphorin/integrin (PSI) domain of the 3 chain of the platelet integrin IIb 3. HPA-1 polymorphism is responsible for neonatal alloimmune thrombocytopenia (NAITP). T-helper response drives anti-HPA-1a production and the putative dominant T-helper epitope is likely to be an important contributory factor in the immunogenicity of HPA-1a. This book provides detailed insight into the molecular mechanism behind of anti-HPA-1a platelet alloimmunization."
Human platelet HPA-1 polymorphism is embedded in the N-terminal plexin/semaphorin/integrin (PSI) domain of the β3 chain of the platelet integrin αIIbβ3. HPA-1 polymorphism is responsible for neonatal alloimmune thrombocytopenia (NAITP). T-helper response drives anti-HPA-1a production and the putative dominant T-helper epitope is likely to be an important contributory factor in the immunogenicity of HPA-1a. This book provides detailed insight into the molecular mechanism behind of anti-HPA-1a platelet alloimmunization.
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