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Ulcerative colitis, a chronic inflammatory disease that mainly affects the colon and rectum, is characterized by ulcers in the intestinal mucosa. Many endogenous systems are involved in intestinal physiology, and the muscarinic system is fundamental to this process. The aim of this study was to investigate the anti-inflammatory action mediated by the M1 muscarinic receptor in acetic acid (AA) colitis. The groups of animals that received 6% intracolonic AA showed a significant increase in the number of lesions in the colon and in the concentration of MPO, MDA and a reduction in GSH levels in...