Pain and Neuroimmune Interactions

ISBN-13: 9781461368977 / Angielski / Miękka / 2013 / 244 str.

Nayef E. Saade; Suhayl J. Jabbur; A. Vania Apkarian

Opis

For those of us involved in research on the neural mechanisms that relate tissue damage to pain. it is becoming more evident that the sensation of pain and suffering could be considered as part of a mechanism that involves not only sizeable areas in the brain but also simultaneous activations of the immune and the endocrine systems as well. A consensus is growing among specialists in the field that pain involves the sharing of molecular mechanisms between the nervous, immune and endocrine systems that can interact at peripheral and, ultimately, central levels. Furthermore, chronic pain could then be looked upon as a corollary of the imbalance in the cross talk between these systems, which could lead to new treatment strategies. The aim of this book is not to deal with acute pain that serves as an alarm signal, but to attempt to explain the molecular mechanisms of chronic pains considered as a multifactorial syndrome or disease.

Spis treści

Foreword. Acknowledgements. I: Nociceptors and Proinflammatory Mediators. 1. Persistent hyperalgesia and cytokines; S.H. Ferreira, et al. 2. Nociceptor excitation by sensitization: A novel hypothesis, its cellular and molecular background; P.W. Reeh, G. Pethö. 3. Tachykinins in visceral pain and hyperalgesia; F. Cervero, J.M.A. Laird. 4. Bradykinin, cytokines and inflammatory hyperalgesia; S. Poole, et al. II: Hyperalgesia: Peripheral and Central Mechanisms. 5. Neurotransmitter and inflammatory correlates in experimental neuropathy: Modulation by electric spinal cord stimulation; B. Linderoth, et al. 6. Diffuse noxious inhibitory controls and arthritis in the rat; N. Danziger, et al. 7. NSAIDs and some safe strategies of their use: spinal c-fos protein studies in carrageenan model of inflammatory nociceptive processes; J. Buritova, J.-M. Besson. 8. The role of dorsal root reflexes in neurogenic inflammation and pain; W.D. Willis, et al. 9. Pain and Neurogenic inflammation: A neural substrate for neuroendocrine - immune interactions; N.E. Saadé, et al. III: Pain and Central Neuroimmune Mechanisms. 10. Thymic peptides: Transmitters between the Neuroendocrine and immune system; M. Dardenne, et al. 11. Thymulin and inflammatory pain: A possible Substrate for PGE2 dependent neuroimmune loop; B. Safieh-Garabedian, et al. 12. The role of peripheral and brain-borne cytokines in immune-neuro-endocrine interactions; H.O. Besedovsky, et al. 13. Interleukin-1 receptors and ligandsin the nervous system; F. Haour, E. Dicou. 14. Biphasic modulation of pain by hypothalamic cytokines; T. Hori, et al. IV: Pain Consciousness and Limbic Mechanisms. 15. In search of pain consciousness or pain and the metaphysics of a Porsche 911; A.V. Apkarian. 16. How do strokes cause pain? R. Tasker. 17. Chronic pain: Somatic or limbic mechanisms; S.J. Jabbur, et al. 18. Where would one seek links between the nervous and immune systems? P.D. Wall. Contributors. Index.