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The objective of the present study was to address challenges in research and development associated with the bitter taste and poor aqueous solubility of Cefuroxime Axetil. The inclusion complex of drug and HP-β-Cyclodextrin and mouth dissolving tablets were prepared. Bitter taste threshold, DSC, PXRD, saturation solubility, in-vitro dissolution studies were carried out for pure drug CA, commercial tablet CEFTUM and CA loaded MDTs. The results support an addition of banana starch to CA-HPβCD inclusion complexes can efficiently aid as an antidiarrheal agent and mask the bitter taste of CA.