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This entirely case-based book covers a broad cross-section of the practical issues frequently encountered in the day-to-day activities of a molecular genetic pathologist. The book is divided into four sections on the principal areas addressed in molecular genetic pathology (MGP): inherited diseases, hematopathology, solid tumors, and infectious diseases. The topics covered by the cases in each section include test selection, qualitative and quantitative laboratory techniques, test interpretation, prognostic and therapeutic considerations, ethical considerations, technical troubleshooting,...

History, archaeology, and human evolutionary genetics provide us with an increasingly detailed view of the origins and development of the peoples that live in Northwestern Europe. This book aims to restore the key position of historical linguistics in this debate by treating the history of the Germanic languages as a history of its speakers. It focuses on the role that language contact has played in creating the Germanic languages, between the first millennium BC and the crucially important early medieval period. Chapters on the origins of English, German, Dutch, and the Germanic language...

Since 1945, the UN has been actively engaged in conceptualizing strategies for both economic development and a sustainable environment. From a broad historical perspective, Development without Destruction sketches the role played by organizations and individuals in the UN system in developing and consolidating principles of international law and international governance with respect to natural resource management. Nico Schrijver highlights the UN's efforts to generate and implement strategies to resolve tensions between economic development and environmental protection, conservation and...

An in-depth overview of polyhedral methods and efficient algorithms in combinatorial optimization. These methods form a broad, coherent and powerful kernel in combinatorial optimization, with strong links to discrete mathematics, mathematical programming and computer science. In eight parts, various areas are treated, each starting with an elementary introduction to the area, with short, elegant proofs of the principal results, and each evolving to the more advanced methods and results, with full proofs of some of the deepest theorems in the area. Over 4000 references to further research...