Jak-Stat Signaling in Diseases

ISBN-13: 9781138487628 / Angielski / Twarda / 2020 / 278 str.

Ritobrata Goswami

Opis

This book discusses the role of Jak-STAT signaling in autoimmune and inflammatory diseases including Asthma, Hepatic fibrosis, Diabetes, Cancer, Inflammatory Bowel Disease, Severe Combined Immunodeficiency, Rheumatoid Arthritis, Dermatology, HIV, Multiple Sclerosis, Renal disorders and Organ Transplantation.

Spis treści

Preface. Editor. List of Contributors. Regulation of Cytokine Signaling by the JAK-STAT Pathway.The Structure-Function Bonhomie of JAK-STAT Molecules. MicroRNA-Mediated Regulation of JAK-STAT Signaling in Non-Cancerous Human Diseases. JAK-STAT Signaling in Asthma and Allergic Airway Inflammation. Role of JAK-STAT Signaling in Atopic Dermatitis. JAK-STAT Signaling Pathway and Gliosis in Neuroinflammatory Diseases. JAK-STAT Signaling in Cardiovascular Disease. Diabetes and Obesity: Abnormal JAK-STAT Signaling. JAK-STAT Signaling in Liver Fibrosis. Renal Disorders: Involvement of Jak-STAT Pathway. JAK-STAT Signaling in Hematologic Malignancies. Aberrant JAK-STAT Signaling in Hematopoietic Malignancies. Immunodeficiency: Consequences of Mutations in JAK-STAT Signaling. Targeting JAK-STAT Pathway for Various Inflammatory Diseases and Viral Infections. Index.

O autorze

Ritobrata Goswami, PhD is presently working as an Assistant Professor in the School of Bioscience, IIT Kharagpur since 2016. Prior to his present affiliation, Dr Goswami was associated with the Division of Biological and Life Sciences, Ahmedabad University (2014-16). He received his bachelor (2005) and masters degree (2007) in Biotechnology from West Bengal University of Technology and Birla Institute of Technology & Science, Pilani; respectively. Dr Goswami obtained his PhD at Indiana University, Indianpolis, USA (2012) followed by post-doctoral training at the Icahn School of Medicine at Mount Sinai, New York, USA (2012-14). He is a life member of the Indian Immunology Society. Dr Goswami has extramural projects funded by the Government of India. Dr Goswami’s research interests include the role of nutrients and hormones in the development and function of T helper cells to regulate inflammatory disorders. He is keen on identifying a regulating network of transcription factors involved in autoimmune and inflammatory disorders so that better therapeutics can be developed.