Hedgehog Signaling Activation in Human Cancer and Its Clinical Implications

ISBN-13: 9781489995414 / Angielski / Miękka / 2014 / 217 str.

Jingwu Xie

Opis

Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients as well as the general public.

Spis treści

Chapter 1- Overview of hedgehog signaling pathway

Chi-chung Hui and Jin Jiang

 

Chapter 2- Regulation of Hh morphogene gradient

G. D’Angelo, F. Wendler, K. Ayers and P.P. Thérond

 

Chapter 3- Smoothened Signaling through a G-protein Effector Network

David J. Robbins and Stacey K. Ogden

 

Chapter 4- Kinases and phosphatases in hedgehog signaling

Jianhang Jia

 

Chapter 5- Signaling Cross-talk of Oncogenic KRAS and Hedgehog Pathways in Pancreatic Cancer

Xiaodong Cheng

 

Chapter 6- Crosstalks between PKC and hedgehog signaling

Jing Li and Mark Evers

 

Chapter 7- Activation of Hh signaling in human cancer

Jingwu Xie and Ervin Epstein

 

 Chapter 8- Hedgehog signaling in pediatric brain tumors

Joon Won Yoon, Ph.D., Jason Fangusaro, M.D., Philip Iannaccone, M.D., Ph.D., and David Walterhouse, M.D.

 

Chapter 9- Hedgehog Signaling in Mammary Gland Development and Breast Cancer

Adriana P. Visbal and Michael T. Lewis

 

Chapter 10- Hedgehog signaling and cancer therapeutic resistance

K.S. Clifford Chao and Yu-Jen Chen

 

Chapter 11- Small-molecule Inhibitors of the Hedgehog Pathway

Ari J. Firestone and James K. Chen

 

Chapter 12- Cyclopamine and its derivatives for cancer therapeutics

Martin Tremblay and Karen McGovern

Blurb

Despite significant progress in our understanding of cancer biology, cancer continues to be the second cause of human mortality. The remarkable responses of cancer patients to inhibitors to the hedgehog signaling pathway implies a promising novel approach to treat cancer. As a result, understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway, initially discovered by two Nobel laureates Drs. E. Wieschaus and C. Nusslein-Volhard in Drosophila, is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. Even more exciting is the discovery and synthesis of specific signaling antagonists for the hedgehog pathway, which have significant clinical implications in novel cancer therapeutics. To provide the most up-to-date information on recent development in this exciting research area, we have invited experts in hedgehog signaling field to summarize major advances made in the last few years on hedgehog signaling mechanisms, activation of the pathway in various human cancer types, potential antagonists for hedgehog signaling inhibition and their clinical implications for human cancer treatment. Authors of the book have also highlighted current challenges in our efforts to translate the basic biology into clinic. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients as well as the general public.