Drug∼nutrient Interactions

ISBN-13: 9789401170833 / Angielski / Miękka / 2012 / 160 str.

T. K. Basu

Opis

In the world at large and in the Western World in particular, the average age of the population is increasing. This is related to an increase in lifespan resulting from remarkable advances in preventive medicine and the clinical sciences. There has also been a concomitant rise of the modern pharmaceutical and chemical industries which support modern treatment methods and influence the pattern of human disease. The science of nutrition has also made major advances in recent years and is poised for even more encouraging contributions as the tools of molecular biology are applied to mechanisms of nutrient effects at the molecular level. Instruction in nutritional science can no longer be restricted to a description of the chemistry of major dietary constituents, diseases associated with a deficiency, and the amounts of nutrients required to prevent them. Modern nutritionists must now address the pervasive interrelationships of long-term nutritional habits and chronic diseases of the cardiovascular system, of cancer, and of osteoporosis, among others. There is also the role of nutrition as a tool in the treatment of post- operative and other patients in the clinical setting. It is at these interfaces that drugs and nutrients interact in significant ways.

Spis treści

1. Introduction.- 1.1 Nature and Origin of Anutrients in the Diet.- 1.2 Potential Carcinogens in Foods.- 1.3 Pharmacological Agents (Drugs).- 1.4 Clinical Implications of Induced Rate of Metabolism of Foreign Compounds.- 2. The Fate of Anutrients in the Body.- 2.1 Metabolism of Foreign Compounds.- 2.2 Nutritional Factors Affecting the Metabolism ofAnutrients.- 2.3 Non-nutritional Dietary Factors Affecting the Metabolism of Anutrients.- 3. Nutritional Consequences of Drug Therapy.- 3.1 Drugs Affecting Food Intake.- 3.2 Drugs Affecting Absorption.- 3.3 Drugs Affecting Carbohydrate Metabolism.- 3.4 Drugs Affecting Lipid Metabolism.- 3.5 Drugs Affecting Protein and Amino Acid Metabolism.- 3.6 Drugs and Vitamin Interactions.- 3.7 Drug and Mineral Interactions.- 3.8 Conclusions.- 4. Alcohol and Nutrition.- 4.1 Alcohol Metabolism.- 4.2 Metabolic Effectsof Alcohol in the Liver.- 4.3 Alcohol and Malnutrition.- 4.4 Alcohol-related Conditions.- 5. Possible Adverse Effects of the Pharmacological Use of Vitamins.- 5.1 Fat-soluble Vitamins.- 5.2 Water-soluble Vitamins.- 5.3 Conclusions.- 6. Drug-Food Interactions.- 6.1 Food Reduces/Delays Drug Absorption.- 6.2 Food Increases Drug Absorption.- 6.3 Food Affecting Urinary Excretion of Drugs.- 6.4 Adverse Reactions Caused by Food.- 7. Nutrition and Experimental Carcinogenesis.- 7.1 Vitamin A (Retinol).- 7.2 ?-Carotene.- 7.3 Vitamin E(?-Tocopherol).- 7.4 Selenium.- 7.5 Vitamin C (Ascorbic Acid).- 7.6 Conclusions.- 8. General Conclusions.- References.