Correlation of PPAR & Diabetic Nephropathy

ISBN-13: 9786205514641 / Angielski / Miękka / 52 str.

Hanan Hanna

Opis

Diabetic nephropathy (DN) is an important and often life-threatening microvascular complication of diabetes mellitus (DM). It is characterized by persistent albuminuria in the range of 30-299 mg/24 h (microalbuminuria), it has been shown to be the earliest sign of renal change.Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that play pivotal roles in the regulation of a very large number of biological processes, such as cell proliferation, cell differentiation, cell death, and inflammatory responses. PPARs include three known subtypes PPAR , PPAR Gamma, and PPARbeta/d. It plays many functional roles in different organs and tissues; adipocyte differentiation, lipid and glucose homeostasis, and insulin sensitivity.

O autorze

Dr.Hanan Hosny, MD chemical pathology, M.B.CH.B. a member in Egyptian Medical Syndicate, Egyptian Society for Laboratory Medicine, and Egyptian Association of Health care Quality & Patient Safety.