Concepts in Viral Pathogenesis

ISBN-13: 9781461297567 / Angielski / Miękka / 2012 / 409 str.

A. L. Notkins; M. B. a. Oldstone

Opis

The current proliferation of scientific information makes it difficult for even the most diligent reader to keep up with the latest developments in his/her own field, let alone other areas of interest. Review articles are one solution, but they too have become so voluminous and detailed that they often defeat the purpose for which they were intended. We have attempted to ease this problem by using a different format. In this volume on Concepts in Viral Pathogenesis, we have assembled a series of mini-reviews/editorials, 1,000 to 2,000 words in length. Each is a pithy distil- lation of the state-of-the-art with emphasis on current thinking and unifying concepts rather than a compendium of the literature. The 53 articles, all written by active workers in their respective fields, are organized systemati- cally so that the book will provide busy investigators, teachers and students of up-to-date information in a very brief and easily read- a conceptual core able form. In addition, the authors have attempted to identify unresolved problems and point to future directions.

Spis treści

Host Control of Viral Spread.- Early Non-immune Control.- 1. Interferon and Viral Pathogenesis.- 2. Natural Killer Cells in Viral Infection.- 3. The Role of the Complement System in Host Defense Against Virus Diseases.- 4. Proteolytic Cleavage and Virus Pathogenesis.- Immune Control—Humoral.- 5. Mechanisms of Virus Neutralization.- 6. Antibody-and Complement-Dependent Lysis of Virus-Infected Cells.- Immune Control—Cellular.- 7. The Inflammatory Response to Acute Viral Infections.- 8. MHC Restriction and Cytotoxic T Lymphocytes.- 9. Antibody-Dependent Cellular Cytotoxicity (ADCC) Mediated by Human Killer Lymphocytes (K-Cells).- 10. Cloning of Functional T Lymphocytes.- Genetic Control.- 11. Host Genes that Influence Susceptibility to Viral Diseases.- 12. Host Genes Controlling the Immune Response.- 13. On the Role of Recombinant Retroviruses in Murine Leukemia.- Host Range and Tissue Tropism.- 14. Viral Receptors: Expression, Regulation and Relationship to Infectivity.- 15. Viral Genes and Tissue Tropism.- 16. Utilization of Host Proteins as Virus Receptors.- 17. Host Range and Tissue Tropisms: Antibody-Dependent Mechanisms.- 18. Enveloped Virus Maturation at Restricted Membrane Domains.- 19. Viruses and Differentiation: The Molecular Basis of Viral Tissue Tropisms.- Virus Maturation and Diversity.- 20. Continuum of Change in RNA Virus Genomes.- 21. Reassortment Continuum.- 22. Immune Selection of Virus Variants.- 23. Antigenic Variants of Viruses and Their Relevance to Clinical Disease.- Virus Persistence.- 24. Unique Interactions of Retroviruses with Eukaryotic Cells.- 25. Molecular Biology of Herpes Simplex Virus Latency.- 26. Cellular Oncogenes and Pathogenesis of Cancer.- 27. Antibody Initiates Virus Persistence: Immune Modulation and Measles Virus Infection.- 28. Ovarian Infection and Transovarial Transmission of Viruses in Insects.- Virus-Interaction with the Immune System.- 29. Virus-Induced Immune Complex Formation and Disease: Definition, Regulation, Importance.- 30. Virus-Induced Autoimmunity.- 31. The Role of Immunospecific Receptors in Retrovirus-Induced Lymphomagenesis.- 32. Viruses as Regulators of Delayed Hypersensitivity T-Cell and Suppressor T-Cell Function.- 33. Mechanisms and Biological Implications of Virus-Induced Polyclonal B-Cell Activation.- Evolving Concepts in Viral Pathogenesis Illustrated by Selected Animal Models.- 34. Virus-Induced Diabetes Mellitus.- 35. Herpesvirus-Induced Atherosclerosis.- 36. Retrovirus-Induced Arthritis.- 37. Virus-Induced Demyelination.- 38. Virus Can Alter Cell Function Without Causing Cell Pathology: Disordered Function Leads to Imbalance of Homeostasis and Disease.- Evolving Concepts in Viral Pathogenesis Illustrated by Selected Diseases in Humans.- 39. Chronic Leukemia.- 40. Hepatitis B Virus Diseases.- 41. Herpesviruses and Cancer.- 42. Epithelial Cell Interactions of the Epstein-Barr Virus.- 43. Viral Gastroenteritis.- 44. Hemorrhagic Fever Viruses.- 45. Marburg and Ebola Viruses: New Agents on the Frontiers of Virology.- 46. Rabies.- 47. Unconventional Viruses.- Control of Viral Diseases.- 48. Antibodies to Synthetic Peptide Immunogens as Probes for Virus Protein Expression and Function.- 49. Recombinant DNA Vaccines.- 50. Monoclonal Antibodies.- 51. Antiviral Drugs.- 52. The Use of Interferons in the Control of Viral Diseases.- 53. Insect Viruses as Pesticides.