Cell Biology

ISBN-13: 9780323758000 / Angielski / Twarda / 2023

Allen Institu Animated Cell CMI (Director PhD MA Graham

Opis

Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods-from single cell RNA sequencing to second generation super resolution fluorescence microscopy-on advancing our understanding.  Clear, readable explanations provide a concise story about how cells function at the molecular level.     An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology.  Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases.  Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation.  Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.  Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. 

Spis treści

1. Section I Introduction to Cell Biology
2. 1.Introduction to Cells
3. 2.Evolution of Life on Earth
5. Section II Chemical and Physical Background
6. 3.Molecules: Structures and Dynamics
7. 4.Biophysical Principles
8. 5.Macromolecular Assembly
9. 6.Research Strategies
11. Section III Chromatin, Chromosomes, and the Cell Nucleus
12. 7.Chromosome Organization
13. 8.DNA Packaging in Chromatin and Chromosomes
14. 9.Nuclear Structure and Dynamics
16. Section IV Central Dogma: From Gene to Protein
17. 10.Gene Expression
18. 11.Eukaryotic RNA Processing
19. 12.Protein Synthesis and Folding
21. Section V Membrane Structure and Function
22. 13.Membrane Structure and Dynamics
23. 14.Membrane Pumps
24. 15.Membrane Carriers
25. 16.Membrane Channels
26. 17.Membrane Physiology
28. Section VI Cellular Organelles and Membrane Trafficking
29. 18.Posttranslational Targeting of Proteins
30. 19.Mitochondria, Chloroplasts, Peroxisomes
31. 20.Endoplasmic Reticulum
32. 21.Secretory Membrane System and Golgi Apparatus
33. 22.Endocytosis and the Endosomal Membrane System
34. 23.Processing and Degradation of Cellular Components
36. Section VII Signaling Mechanisms
37. 24.Plasma Membrane Receptors
38. 25.Protein Hardware for Signaling
39. 26.Second Messengers
40. 27.Integration of Signals
42. Section VIII Cellular Adhesion and the Extracellular Matrix

28.Cells of the Extracellular Matrix and Immune System

43. 29.Extracellular Matrix Molecules
44. 30.Cellular Adhesion
45. 31.Intercellular Junctions
46. 32.Connective Tissues
48. Section IX Cytoskeleton and Cellular Motility
49. 33.Actin and Actin-Binding Proteins
50. 34.Microtubules and Centrosomes
51. 35.Intermediate Filaments
52. 36.Motor Proteins
53. 37.Intracellular Motility
54. 38.Cellular Motility
55. 39.Muscles
57. Section X Cell Cycle
58. 40.Introduction to the Cell Cycle
59. 41.G1 Phase and Regulation of Cell Proliferation
60. 42.S Phase and DNA Replication
61. 43.G2 Phase, Responses to DNA Damage, and Control of Entry Into Mitosis
62. 44.Mitosis and Cytokinesis
63. 45.Meiosis
64. 46.Programmed Cell Death

Appendix

65. Cell SnapShots