Biology of the NMDA Receptor

ISBN-13: 9780367386528 / Angielski / Miękka / 2019 / 350 str.

Antonius M. Vandongen

Opis

The NMDA receptor, a subclass of the ionotropic glutamate receptor family, plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. Biology of the NMDA Receptor describes all importance aspects of NMDA receptor biology. The text highlights exciting new discoveries that have been made over the past decade. It provides a comprehensive review of various molecular genetics studies that illustrate the importance of this class of receptors; in addition, the book presents a discussion of recent crystallographic x-ray structures of its ligand binding domains.

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Spis treści

Introduction. Molecular Genetics of the NMDA Receptor. NMDA Receptors: Learning and Memory. The Role of NMDA Receptors in Organizing Brain Development. NMDA Receptors and Developmental Critical Periods. NMDA Receptors and Spine Morphogenesis. NMDA Receptors and Synaptic Plasticity. NMDA Receptor Signaling to the Nucleus. Trafficking and Targeting of NMDA Receptors. Regulation of NMDA Receptor Function by Phosphorylation. Allosteric Modulation of the NMDA Receptor. Pharmacology of the NMDA Receptor. Activation of the NMDA Receptor. Structural Biology of the NMDA Receptor.

O autorze

Antonius M. VanDongen