Bile Acids in Health and Disease: Update on Cholesterol Gallstones and Bile Acid Diarrhoea

ISBN-13: 9789401070546 / Angielski / Miękka / 2011 / 288 str.

T. C. Northfield; P. Zentler-Munro; R. Jazwari

Opis

Bile acids occupy a central position in in the absorption, excretion and metab- olism of lipids within the body. Our understanding of their unique properties has illuminated many biochemical and biophysical processes. Animals have evolved a unique system of preserving these important detergent-like molecules within the body and reusing them many times - the enterohepatic circulation. Disorders of the enterohepatic circulation contribute to a correspondingly wide range of diseases, and recent developments have centred in particular on cholesterol gallstone disease and bile acid diarrhoea. Successful manage- ment of these diseases is increasingly based on an understanding of the physicochemical and biochemical properties of bile acids, and of their pathophysiological role in disease. Professor Alan Hofmann starts this book with an overview of the enterohepatic circulation of bile acids. The first section then discusses biliary lipid synthesis, transport and secretion by the liver and the solubilisation of cholesterol in the bile. The next section applies this knowledge to the pathogenesis of cholesterol gallstones. Separate chapters focus on defects in biliary lipid secretion, in cholesterol solubilisation and in gallbladder motility. The succeeding sections then review posssible approaches to gallstone prevention, and assess recent developments in non-surgical forms oftreatment. Two exciting new therapies that receive particular attention are contact dissolution therapy with methyl tert-butyl ether and extracorporeal shock wave lithotripsy. Further sections turn to the absorptive functions of bile acids in health.

Spis treści

1 Overview: the enterohepatic circulation of bile acids — a topic in molecular physiology.- Section A Biliary Chemistry And Physiology.- 2 Hepatic bile acid transport and secretion.- 3 Hepatic biliary lipid synthesis and transport.- 4 Biliary lipid secretion and its control.- 5 Lipid solubilisation in bile.- 6 Gallbladder motor function.- Section B Pathogenesis Of Cholesterol Gallstone Disease.- 7 The secretory defect.- 8 The physico-chemical defect.- 9 The motility defect.- Section C Gallstone Prevention.- 10 Clues from epidemiology.- 11 Post-dissolution trials.- Section D Non-Surgical Treatment Of Gallstones.- 12 Cheno- versus ursodeoxycholic acid.- 13 Cheno- plus ursodeoxycholic acid.- 14 Methyl tert-butyl ether.- 15 Lithotripsy.- 16 Overall strategy.- Section E Lipid Digestion And Bile Acid Absorption.- 17 Fat digestion and solubilisation.- 18 Bile acid absorption.- Section F Lipid Maldigestion And Bile Acid Malabsorption.- 19 Fat digestion and solubilisation in disease.- 20 Bile acid malabsorption, diarrhoea and steatorrhoea.- 21 Bile acids in irritable bowel syndrome.- Section G Diagnosis Of Bile Acid Malabsorption — Role Of 75SeHCAT.- 22 75SeHCAT: an overview of its physiological properties and clinical value.- 23 Whole body and abdominal retention of75SeHCAT.- 24 Gallbladder retention of 75SeHCAT.