Born in Cambridge City near Hagerstown, Indiana, Wissler graduated from Indiana University in 1897. He received his doctorate in psychology from Columbia University in 1901. After Columbia, Wissler left the field of psychology to focus on Anthropology. Clark Wissler worked at the American Museum of Natural History as a Curator in ethnology from 1902 to 1907. In 1907 Wissler was named Curator of Anthropology when the Archaeology and Ethnology departments were recombined under the Department of Anthropology. Clark Wissler was the first anthropologist to perceive the normative aspect of culture,