Xenotransplantation: Basic Research and Clinical Applications

ISBN-13: 9781617371271 / Angielski / Miękka / 2010 / 284 str.

Jeffrey L. Platt

Opis

Internationally recognized scientists, clinicians, and technologists review and explain the fundamental molecular and cellular biology that has been applied to the emerging field of transplant immunology and xenotransplantation, and what impact these advances might optimally have on medicine and science. The authoritative experts writing here-many of whom made the basic discoveries underlying the recent advances-examine the biological and immunological hurdles to xenotransplantation, illuminating how the immune system interacts with the xenograft and laying a practical foundation for the use of genetic engineering and animal transplants in the treatment of human disease.

Recenzje

"This book provides a useful and concise review of the current status of xenotransplantion and introduces the reader to the remaining required developments before effective implementation of xenotransplantation can occur...The editor and authors are recognized authorities in the field of xenotransplantation and this book is an important addition to existing literature on this topic" - Doody's Health Sciences Book Review Journal

Spis treści

Molecular and Cellular Hurdles to Xenotransplantation Jeffrey L. Platt Pathological Responses to Xenotransplantation Matilde Bustos and Jeffrey L. Platt Natural Xenoreactive Antibodies Uri Galili Specificity of Xenoreactive Natural Antibodies William Parker, Paul B. Yu, and Yuko C. Nakamura Biophysical Properties of Xenoreactive Natural Antibodies William Parker, Ryan C. Fields, and Yuko C. Nakamura The Origin of Xenoreactive Natural Antibodies Paul B. Yu Synthesis of Carbohydrate Antigens Recognized by Xenoreactive Antibodies Mauro S. Sandrin and Ian F. C. McKenzie The Complement Barrier to Xenotransplantation Agustin P. Dalmasso Defects and Amplification of Costimulation Across the Species Nicola Rogers and Robert Lechler Antibody-Dependent Effects on Cellular Immunity Antonello Pileggi, R. Damaris Molano, Thierry Berney, and Luca Inverardi Disordered Regulation of Coagulation and Platelet Activation in Xenotransplantation Simon C. Robson Current Applications of Cellular Xenografts Albert S. B. Edge Index

Blurb

Xenotransplantation might well provide a revolutionary way of augmenting the function of diseased tissues or replacing organs. This possibility has been advanced by newly acquired understanding of the biological and immunological obstacles to conducting transplantation between species. In Xenotransplantation: Basic Research and Clinical Applications, internationally recognized scientists, clinicians, and technologists review and explain the fundamental molecular and cellular biology that has been applied to the emerging field of transplant immunology and xenotransplantation and what impact these advances might optimally have on medicine and science. The authoritative experts writing here-many of whom made the basic discoveries underlying the recent advances-examine the biological and immunological hurdles to xenotransplantation, illuminating how the immune system interacts with the xenograft, and laying a practical foundation for the use of genetic engineering and animal transplants in the treatment of human disease.
Comprehensive and authoritative, Xenotransplantation: Basic Research and Clinical Applications provides basic and clinical investigators, as well as transplant surgeons, with today's most thorough and up-to-date compendium of vital information on all the scientific and technological aspects of xenotransplantation.