Werner's Syndrome and Human Aging

ISBN-13: 9781468478556 / Angielski / Miękka / 2012 / 656 str.

Darrell Salk

Opis

In keeping with the traditions of deve1opmenta1 bio1ogy and geronto1ogy, there was a long incubation period before fu11 expres- sion of the plans for an International Conference on the Werner Syndrome and the pub1ication of the present monograph based upon the proceedings of that conference. The initial concept emerged at the Xlth International Congress. of Geronto1ogy, which took p1ace in Tokyo in 1978. Drs. G.M. Martin, Y. Fujiwara and Y. Mitsui met on that occasion to discuss ways of acce1erating the pace of research on this important disorder, inc1uding banking and sharing of ce11 cu1tures, establishment of patient registries, and p1anning of joint conferences and pub1ications. In November 1979, under the auspices of the Geronto1ogica1 Society of America and a conference grant from the National Institute on Aging of the U.S. National Institutes of Hea1th, a group of Japanese investigators (Drs. Fujiwara, Mitsui, M. Goto, T. Ishii, K. Oota and -T. Matsumura) met with Drs. Martin, D. Sa1k and W. Ted Brown to deve10p plans to implement the goals discussed at the initial Tokyo meeting. A workshop focused on the needs of ce11 banking and 1ed to an accumu1ation of research materials both in Japan (main1y under the leadership of T. Matsumura) and in the U.S.A. (with the cooperation of Dr. Arthur Greene of the Institute of Medica1 Research).

Spis treści

Historical Perspective.- On Cataract in Conjunction with Scleroderma.- Werner’s Syndrome (Progeria of the Adult) and Rothmund’s Syndrome: Two Types of Closely Related Heredofamilial Atrophic Dermatoses with Juvenile Cataracts and Endocrine Features; a Critical Study with Five New Cases.- Werner’s Syndrome: A Review of its Symptomatology, Natural History, Pathologic Features, Genetics and Relationship to the Natural Aging Process.- Werner Syndrome: A Review of Recent Research with an Analysis of Connective Tissue Metabolism, Growth Control of Cultured Cells, and Chromosomal Aberrations.- Clinical, Pathological and Genetic Aspects of the Werner Syndrome and Normal Human Aging.- Genetics and Aging: Werner’s Syndrome as a Segmental Progeroid Syndrome.- Clinical, Endocrine and Metabolic Aspects of the Werner Syndrome Compared with Those of Normal Aging.- Pathology of the Werner Syndrome.- Neuropathology of the Werner Syndrome.- Werner’s Syndrome and Aging: A Reappraisal.- A Comparison of Adult and Childhood Progerias: Werner Syndrome and Hutchinson-Gilford Progeria Syndrome.- Clinical, Demographic and Genetic Aspects of the Werner Syndrome in Japan.- Immunological Aspects of the Werner’s Syndrome: An Analysis of 17 Patients.- Clinical and Metabolic Studies on the Werner’s Syndrome: With Special Reference to Disorders of Lipid and Liver Function.- Growth Control of Werner Syndrome Cells In Vitro.- Growth Characteristics of Werner Syndrome Cells in Vitro.- Studies of SV40-Infected Werner Syndrome Fibroblasts.- Experimental Studies on Werner’s Syndrome Fibroblasts.- Cell Fusion Studies in the Werner Syndrome.- Cell Fusion Studies and Biochemical Analysis of DNA Synthesis in Werner and Non-Werner Cultured Cells.- Molecular Mechanisms of Cellular Senescence: DNA Metabolism and Chromatin Change.- Histone H1 in G1 Arrested, Senescent and Werner Syndrome Fibroblasts.- Genome Reorganization During Aging of Dividing Cells.- Cellular Mechanisms of Ageing in the Werner Syndrome.- Autoradiographic Studies of DNA Replication in Werner’s Syndrome Cells.- Abnormal Fibroblast Aging and DNA Replication in the Werner Syndrome.- Extrachromosomal Circular DNA and Aging Cells.- Molecular Mechanisms of Cellular Senescence: Errors in Protein Synthesis.- Protein Synthetic Fidelity in Aging Human Fibroblasts.- Analysis of Cellular Senescence through Detection and Assessment of RNAs and Proteins Important to Gene Expression: Transfer RNAs and Autoimmune Antigens.- Cytogenetics of the Werner Syndrome.- Cytogenetic Aspects of Werner Syndrome.- A Population and Cytogenetic Study of the Werner Syndrome in Sardinia.- Connective Tissue Metabolism and Disturbances in the Werner Syndrome.- Proteoglycans in the Werner Syndrome and Aging: A Review and Perspective.- Cell Surface Changes in Senescent and Werner’s Syndrome Fibroblasts: Their Role in Cell Proliferation.- Acidic Glycosaminoglycans in Werner’s Syndrome: Studies on Levels in Tissue, Organ, Cell and Fluid.- Acidic Glycosaminoglycans of SV40-Transformed Werner’s Syndrome Cells.- Glycosaminoglycan Synthesis in Untransformed and Transformed Werner Syndrome Fibroblasts: A Preliminary Report.- Gene Action, Development and Aging: New Directions for Research in the Werner Syndrome.- The Notion of Primordial Building Blocks in Construction of Genes and Transcriptional and Processing Errors due to Random Occurrence of Oligonucleotide Signal Sequences.- Appearance of Albumin-Producing Cells in the Liver of Anabulminemic Rats on Aging and Administration of Mutagens.