Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Volume 2

ISBN-13: 9781461460541 / Angielski / Miękka / 2013 / 548 str.

Michael F. Holick

Opis

In Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition, Volume 1, leading researchers provide a comprehensive, highly readable overview of the biological functions and clinical applications of vitamin D and its metabolites. Presented in a newly affordable softcover format this volume contains Parts IV through VII of the previously published hardcover text. Topics range from the most recent recommendations for vitamin D intake to new approaches for the treatment and prevention of vitamin D deficiency and the development of active vitamin D drugs to treat psoriasis and cancer. The book demonstrates the significant role that vitamin D has in maintaining good bone health and the prevention of osteoporosis, an important health problem for adults over the age of fifty. In addition, it authoritatively reviews the relationship between sunlight exposure, vitamin D, and increased risk of colon and breast cancer; how vitamin D is made in the skin; and the sequence of events that leads to its activation by the kidney. Also examined are the biological functions of 1,25-dihydrovitamin D3 on the intestine and bone, as well as other tissues, such as skin, the immune system, prostate, and breast, and vitamin D's molecular mechanism of action on the cell membrane and nucleus. Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition, Volume 2 is designed and organized not only to be an up-to-date review on the subject, but also to provide medical students, graduate students, health care professionals and even the lay public with a reference source for the most up-to-date information about the vitamin D deficiency pandemic and its clinical implications for health and disease.

Spis treści

Vitamin D Deficiency in Pregnancy and Lactation and Health Consequences.- Vitamin D Deficiency in Children and Its Health Consequences.- Dietary Calcium Deficiency and Rickets.- Vitamin D in Fracture Prevention and Muscle Function and Fall Prevention.- Inherited Defects of Vitamin D Metabolism.- Molecular Defects in the Vitamin D Receptor Associated with Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets (HVDRR).- Receptor-Independent Vitamin D Resistance in Subhuman and Human Primates.- 25-Hydroxyvitamin 1α-Hydroxylase: Studies in Mouse Models and Implications for Human Disease.- The Health Benefits of Solar Irradiance and Vitamin D and the Consequences of Their Deprivation.- Vitamin D Status, Solar Radiation and Cancer Prognosis.- The Epidemiology of Vitamin D and Cancer Risk.- Vitamin D Deficiency and the Epidemiology of Prostate Cancer.- Vitamin D for Cancer Prevention and Survival.- The Anti-Cancer Effect of Vitamin D: What Do the Randomized Trials Show?- Sunlight, Skin Cancer, and Vitamin D.- Vitamin D and the Risk of Type 1 Diabetes.- Vitamin D and Multiple Sclerosis.- Vitamin D and Type 2 Diabetes.- Role of Vitamin D for Cardiovascular Health.- Vitamin D, Renin, and Blood Pressure.- Role of Vitamin D and Vitamin D Analogs for Bone Health and Survival in Chronic Kidney Disease.- Role of Vitamin D in Rheumatoid Arthritis.- Vitamin D, Respiratory Infections, and Obstructive Airway Diseases.- Treatment of Immunomediated Diseases by Vitamin D Analogs.- Clinical Utility of 1, 25-Dihydroxyvitamin D₃  and Its Analogues for the Treatment of Psoriasis.- Affinity Alkylating Vitamin D Analogs as Molecular Probes and Therapeutic Agents.- Anti-inflammatory Activity of Calcitriol That Contributes to Its Therapeutic and Chemopreventive Effects in Prostate Cancer.

Blurb

In Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition, Volume 2, leading researchers provide a comprehensive, highly readable overview of the biological functions and clinical applications of vitamin D and its metabolites. Presented in a newly affordable softcover format this volume contains Parts IV through VII of the previously published hardcover text. Topics range from the most recent recommendations for vitamin D intake to new approaches for the treatment and prevention of vitamin D deficiency and the development of active vitamin D drugs to treat psoriasis and cancer. The book demonstrates the significant role that vitamin D has in maintaining good bone health and the prevention of osteoporosis, an important health problem for adults over the age of fifty. In addition, it authoritatively reviews the relationship between sunlight exposure, vitamin D, and increased risk of colon and breast cancer; how vitamin D is made in the skin; and the sequence of events that leads to its activation by the kidney. Also examined are the biological functions of 1,25-dihydrovitamin D3 on the intestine and bone, as well as other tissues, such as skin, the immune system, prostate, and breast, and vitamin D's molecular mechanism of action on the cell membrane and nucleus.

Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition, Volume 2 is designed and organized not only to be an up-to-date review on the subject, but also to provide medical students, graduate students, health care professionals and even the lay public with a reference source for the most up-to-date information about the vitamin D deficiency pandemic and its clinical implications for health and disease.