Viral Gastroenteritis: Molecular Epidemiology and Pathogenesis

ISBN-13: 9780128022412 / Angielski / Miękka / 2016 / 588 str.

Lennart Svensson; Ulrich Desselberger; Mary K. Estes

Opis

Viral Gastroenteritis: Molecular Epidemiology and Pathogenesis provides a comprehensive review of research on viruses causing acute gastroenteritis in infants and young children, including coverage of rotaviruses, human caliciviruses, astroviruses, enteric adenoviruses, and viruses causing gastroenteritis more rarely. Includes general chapters on gastrointestinal physiology and pathophysiology, gastrointestinal immune mechanisms, immunodeficiencies and host genetics influencing susceptibility to viral gastroenteritis, and therapeutic and preventative approaches. The book also includes special sections on virus particle structures, replication cycles, pathogenesis, immunology, epidemiology, and preventative measures. This book covers both basic science and translational applications and is an appropriate resource for virologists, molecular biologists, epidemiologists, gastroenterologists, vaccinologists, and those with an interest in public health.

• Features new approaches in diagnosis and characterization of viral gastroenteritis pathogens
• Includes coverage of therapeutic and preventative methods
• Covers recent advances in characterizing the molecular biology and immune responses of rotaviruses and noroviruses
• Covers both basic science and translational applications and is an appropriate resource for virologists, molecular biologists, epidemiologists, gastroenterologists, vaccinologists, and those with an interest in public health

Spis treści

1. Gastrointestinal physiology and pathophysiology2. Gastrointestinal immunity3. Host genetics and susceptibility to gastrointestinal infections4. Immunodeficiencies, in particular IgA deficiency5. Metagenomics of viruses infecting the gut6. Gut microbiota and disease7. Therapy of gastroenteritis8. Rotavirus9. Structure function10. Replication (4-5 chapters)11. Pathogenesis (2 chapters)12. Immunology (2 chapters)13. Molecular epidemiology and evolution14. Vaccine and therapeutic developments and implementation (2 chapters) - Human caliciviruses - Structure function - Replication (2 chapters) - Animal models - Epidemiology and evolution (2 chapters) - Vaccine development - Astroviruses - Structure function - Replication (2 chapters) - Epidemiology - Other viruses causing gastroenteritis - Aichi virus - Enteroviruses - Picobirnavirus

O autorze

Lennart Svensson is the Professor of Molecular Biology at Linköping University. He is presently researching virus disease mechanisms and the human genetics of susceptibility, with particular focus on the rotavirus and the norovirus.During his research, he and his team have contributed many important observations to the field regarding the processes of and reactions to these viruses in the human body. Ulrich Desselberger is a Professor in the Department of Medicine, of which he is the director, at the University of Cambridge whilst also actively consulting. He specialises in the molecular biology of rotaviruses. Mary K Estes is the Professor of Virology and Microbiology at Baylor College of Medicine. Mary specialises in gastrointestinal viruses. Her academic career has seen her win many accolades including the Presidency of the American Society for Virology, and more recently the AGA Distinguished Achievement Award. Harry B Greenberg is a Professor of the department of Microbiology and Immunology at the Stanford School of Medicine. On top of this position he also holds the Jospeh D Grant Professorship, is Director of Spectrum and the Senior Associate Dean for Research. Amongst his honors and awards, he has served as president of the American Society of Virology.