Vessel Wall in Athero- And Thrombogenesis: Studies in the USSR

ISBN-13: 9783540113843 / Angielski / Miękka / 1982 / 226 str.

E. I. Chazov; V. N. Smirnov

Opis

Mankind in the second half of the twentieth century has encountered a number of social and economic problems, which, as never before, determine its future. Among the main problems facing medicine, meriting distinction is organization of the struggle against the increase of cardiovascular and oncological diseases which, with the birthrate, are the main demographic indices of our planet. According to the World Health-Organization, the deathrate from diseases of the cardiovascular system has risen by 60% in recent years, and there has been a sharp increase of myocardial infarctions and cases of sudden death in young people aged 25-30. The "geography" of heart and blood vessel diseases has changed: a dramatic increase of morbidity has been recorded in rural regions, and in districts where 10-20 years ago the native population was practically unaffected by atherosclerosis. Diseases of the cardiovascular system have become widespread among women as well as men. Cardiovascular diseases tax the national economy: they are responsible for over half the mortality among people at the prime of their productive life. More than 50% of temporary disability is also accounted for by ischemic heart disease, hypertension, stroke, etc.

Spis treści

Elements of Vessel Wall.- On the Endothelial Lining of Human Arteries at Genesis of the Atherosclerotic Plaque.- Endothelial Injury and Polymorphism: A Quantitative Analysis by Scanning Electron Microscopy.- Functional Characteristics of the Endothelium in the Dynamics of Experimental Atherosclerosis Development.- Morphological Analysis of Cells Isolated from the Intima and Media of Human Aorta.- Functional and Metabolic Characterization of Cells from Normal and Atherosclerotic Human Aorta.- The Collagen-Elastic Framework of Major Arteries.- Structural Changes of the Vascular Wall in Regional Hemodynamic Disturbances.- Complex Formation of Low Density Lipoproteins with Glycosaminoglycans in the Arterial Wall.- Vessel Wall and Lipoproteins.- The Role of Apoproteins in Determination of Atherogeneity or Antiatherogeneity of Blood Plasma Lipoproteins.- Interaction of Lipoproteins and Apoproteins with Bilayer Lipid Membranes.- Features of Composition and Structure of High Density Lipoproteins at Disulphatlipoproteinemias According to Spin Label Electron Paramagnetic Resonance Spectroscopy Data.- Mechanism of Lipoprotein Uptake into the Arterial Wall.- Interaction of Lipoproteins with Foam Cells.- A Biochemical and Morphological Study of Arterial Wall and Blood Plasma Lipids in Human Atherosclerosis.- Interaction of Fluorescently-Labeled Low Density Lipoproteins with Human Aortic Cells in the Primary Culture.- Demonstration and Features of Low Density Lipoprotein Binding to Platelets.- Vessel Wall and Platelets.- A Model for Studying Platelet Interaction with Cellular and Macromolecular Constituents of the Vessel Wall In Vitro.- Targeted Liposome Transport to the Reconstituted Vessel Wall.- Adhesive and Thrombogenic Properties of Human Vascular Wall Cells in Culture.- Platelet Shape Regulation.- Advances and Perspectives of Thrombo- and Atherogenesis Studies in the USSR.