Vertebrate Motoneurons

ISBN-13: 9783031071690 / Angielski / Miękka / 2023

Opis

This book aims to provide a comprehensive and timely review of new findings in motoneuron research. Recent findings have revealed that motoneurons are more complex and have more extensive functions than previously imagined. Some of the molecular and genetic pathways that orchestrate the development of motoneurons have been discovered, as have the mechanisms responsible for the selective innervation of muscles by specific pools of motoneurons. These novel findings are revolutionizing ideas about the function of motoneurons and have important implications for motoneuron disease.  Chapters from several of the foremost figures in the field are included in this book and will emphasize how basic science is the engine driving the discovery of novel treatments for degenerative motoneuron diseases. Cutting edge developments in the use of pluripotent stem cells to correct motoneuron disease will be also be covered.  This book would be useful to students of basic motoneuron physiology, locomotor behavior and motor control. This book would also be of interest to professional neuroscientists, neurologists, and neurosurgeons.

Spis treści

Part-1 MOTONEURON DEVELOPMENT

1.     ESTABLISHING THE MOLECULAR AND FUNCTIONAL DIVERSITY OF SPINAL MOTONEURONS

Jeremy S. Dasen

NYU Neuroscience Institute, Department of Neuroscience and Physiology, NYU School of Medicine, New York, NY 10016, USA

2.     CHLORIDE HOMEOSTASIS IN DEVELOPING MOTONEURONS

Pascal Branchereau and Daniel Cattaert

Univ. Bordeaux, CNRS, INCIA, UMR 5287, Bordeaux, France

3.     NORMAL DEVELOPMENT AND PATHOLOGY OF MOTONEURONS: ANATOMY, ELECTROPHYSIOLOGICAL PROPERTIES, FIRING PATTERNS AND CIRCUIT CONNECTIVITY

Joshua I. Chalif, and George Z. Mentis

Center for Motor Neuron Biology and Disease, Departments of Neurology and Pathology & Cell Biology

Columbia University, New York, NY, USA.

Department of Neurosurgery, Brigham and Women’s Hospital, Harvard University, Boston, MA, USA

 

4.     HOMEOSTATIC REGULATION OF MOTONEURON PROPERTIES IN DEVELOPMENT

Peter A. Wenner, Dobromila Pekala

Department of Cell Biology, Emory University, School of Medicine, Atlanta, GA 30340.

 

 

Part-2 MOTONEURON CONNECTIVITY AND FUNCTION

5.     HOMEOSTATIC PLASTICITY OF THE MAMMALIAN NEUROMUSCULAR JUNCTION

Kathrin L. Engisch, Xueyong Wang and Mark M. Rich

Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH, 45435.

 

 

 

6.     DIVERSITY OF MAMMALIAN MOTONEURONS AND MOTOR UNITS

Marcin Bączyk, Marin Manuel, Francesco Roselli, Daniel Zytnicki

Poznań University of Physical Education, Department of Neurobiology, Poznan, Poland

Université de Paris, SPPIN - Saints-Pères Paris Institute for the Neurosciences, CNRS, Paris, 75006, France

Dept. of Neurology, Ulm University, 89081 Ulm, Germany

Institute of Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany

German Center for Neurodegenerative Diseases (DZNE)-Ulm, 89081 Ulm, Germany

Neurozentrum Ulm, 89081 Ulm, Germany

 

7.     SYNAPTIC PROJECTIONS OF MOTONEURONS WITHIN THE SPINAL CORD

Marco Beato and Gary Bhumbra

Department of Neuroscience Physiology and Pharmacology, University College London, London, United Kingdom.

8.     RECRUITMENT OF MOTONEURONS

Vatsala Thirumalai, Urvashi Jha

National Centre for Biological Sciences, Bellary Road, Bangalore 560065.

 

9.     ELECTRICAL PROPERTIES OF ADULT MAMMALIAN MOTONEURONS

Calvin C. Smith, Robert M. Brownstone

Department of Neuromuscular Diseases, University College London, London, United Kingdom.

10.  THE CELLULAR BASIS FOR THE GENERATION OF FIRING PATTERNS IN HUMAN MOTOR UNITS

Obaid U. Khurram, Gregory E. P. Pearcey, Matthieu K. Chardon, Edward H. Kim, Marta García, and C.J. Heckman

Departments of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL; Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, IL; Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL; Computational Science Division, Argonne National Laboratory, Lemont, IL; Northwestern-Argonne Institute of Science and Engineering, Evanston, IL.

 

11.  MOTONEURONAL REGULATION OF CENTRAL PATTERN GENERATOR AND NETWORK FUNCTION

Melanie Falgairolle and Michael J. O’Donovan

NCCIH,NINDS, NIH, Bethesda USA.

 

12.  EXTRAOCULAR MOTONEURONS AND NEUROTROPHISM

Angel M Pastor, Roland Blumer and Rosa R. de la Cruz

Departamento de Fisiología, Universidad de Sevilla, Spain.

Center of Anatomy and Cell Biology. Medical University of Vienna. Austria

 

Part-3 MOTONEURON DISEASE

13.  MOTONEURON DISEASES

Francesco Lotti, Serge Przedborski

Departments of Pathology & Cell Biology, Neurology, and Neuroscience, Columbia University, New York, New York, USA.

14.  ELECTRICAL AND MORPHOLOGICAL PROPERTIES OF DEVELOPING MOTONEURONS IN POSTNATAL MICE AND EARLY ABNORMALITIES IN SOD1 TRANSGENIC MICE

Jacques Durand, Anton Filipchuk

Institut de Neurosciences de la Timone (INT) P3M team, Aix Marseille Université CNRS UMR 7289, 27 bd Jean Moulin 13385 cedex 05 France.

Paris-Saclay Institute of Neuroscience (NeuroPSI), Department for Integrative and Computational Neuroscience (ICN), UMR9197 CNRS/University Paris Sud, CNRS Bldg. 22 32/33, 1 Av. de la Terrasse, 91190 Gif-sur-Yvette,

 

15.  FROM PHYSIOLOGICAL PROPERTIES TO SELECTIVE VULNERABILITY OF MOTOR UNITS IN AMYOTROPHIC LATERAL SCLEROSIS

Marcin Bączyk, Marin Manuel, Francesco Roselli, Daniel Zytnicki

Poznań University of Physical Education, Department of Neurobiology, Poznan, Poland

Université de Paris, SPPIN - Saints-Pères Paris Institute for the Neurosciences, CNRS, Paris, 75006, France

Dept. of Neurology, Ulm University, 89081 Ulm, Germany

Institute of Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany

German Center for Neurodegenerative Diseases (DZNE)-Ulm, 89081 Ulm, Germany

Neurozentrum Ulm, 89081 Ulm, Germany

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