Vascular Mechanisms in CNS Trauma

ISBN-13: 9781461486893 / Angielski / Twarda / 2013 / 518 str.

Eng H. Lo; Josephine Lok; Mingming Ning

Opis

While there are a number of books on the market that deal with neuronal mechanisms and targets, the proposed book will be the only one to cover the vascular aspects of CNS trauma. The contributing authors will present basic mechanisms, explain cutting-edge experimental models and techniques, and provide several clinical chapters that provide treating physicians with some insight on the cases that they see in the ICU. The table of contents is diverse and comprehensive with chapters on molecular mechanisms, physiology, pharmacology, stem cells, genomics and proteomics, in vivo MRI and PET, as well as the clinical management of vascular parameters.​

Recenzje

From the reviews:

"This textbook on cerebral blood flow and physiology of head injury is worth reading for graduate students, experts in the head trauma research, and also to seasoned investigators. The work is done for the historical origins, developments over the past 30 years and especially the current literature. ... this is an excellent textbook for all neurophysiologists and stroke researchers from student to experts ... ." (Joseph J. Grenier, Amazon.com, December, 2013)

Spis treści

Part I: Molecular Mechanisms

 

1. CNS Barriers in Neurotrauma

Adam Chodobski, Brian J. Zink, and Joanna Szmydynger-Chodobska

 

2. Mechanisms of Cerebral Edema Leading to Early Seizures after Traumatic Brain Injury

Philip H. Iffland II, Gerald G. Grant and Damir Janigro

 

3. Human Cerebral Blood Flow and Traumatic Brain Injury

David A. Hovda and Thomas C. Glenn

 

4. Gliovascular Targets in Traumatic CNS Injury

Arjun Khanna^, Brian P Walcott, Kristopher T Kahle, Volodymyr Gerzanich, J. Marc Simard

 

5. Neurovascular Responses to Traumatic Brain Injury

Josephine Lok, Ken Arai, Shu-zhen Guo, Wendy Leung, Takakuni Maki, Deepti Navaratna, Klaus van Leyen, Changhong Xing, and  Eng H. Lo

 

6. The Effects of Intravascular Coagulation and Microthrombosis on Cerebral Perfusion after Brain Trauma

Monisha A. Kumar, Doug H. Smith, and Sherman C. Stein

 

7. Barriers to Drug Delivery for Brain Trauma

Robert S. B. Clark

 

8. Angiogenesis and Functional Recovery after Traumatic Brain Injury

Yanlu Zhang, Ye Xiong, Asim Mahmood, Zheng Gang Zhang, and Michael Chopp

 

9. Vascular Mechanisms in Spinal Cord Injury

Theo Hagg

 

10. Neurovascular Mechanisms of Ischemia Tolerance Against Brain Injury

Kunjan R. Dave, John W. Thompson, Jake T. Neumann, Miguel A. Perez-Pinzon, Hung W. Lin

 11. Stem Cells for Neurovascular Repair in CNS Trauma

Mibel M. Pabón, Travis Dailey, Naoki Tajiri, Kazutaka Shinozuka, Hiroto Ishikawa, Sandra Acosta, Yuji Kaneko, Cesar V. Borlongan

 

12. Vascular Actions of Hypothermia in Brain Trauma

W. Dalton Dietrich and Helen M. Bramlett

 

Part II: Experimental Models and Methods

13. Vascular Responses in Rodent Models of Traumatic Brain Injury

Xiaoshu Wang, Zhanyang Yu, Zhengbu Liao, Qi Liu, MingMing Ning, Xiaochuan Sun, Josephine M. Lok, Eng H. Lo, Xiaoying Wang

 

14. SAH Models: Review, New Modification, and Prospective

Sheng Chen, Damon Klebe, Alexander Vakhmyanin, Mutsumi Fujii, John H. Zhang

 

15. Age and Sex Differences In Hemodynamics In a Large Animal Model of Brain Trauma

William M. Armstead and Monica S. Vavilala

 

16. Neutrophils as Determinants of Vascular Stability in the Injured Spinal Cord

Alpa Mahuvakar, Sang Mi Lee, Haoqian Zhang, and Linda J. Noble-Haeusslein

 

17. Blood Biomarkers for Acute CNS Insults: Traumatic Brain Injury and Stroke

Olena Glushakova, Stefania Mondello, Ronald L. Hayes

 

18. Biomaterials for CNS Injury

Myron Spector and Teck Chuan Lim

 

19. Isolated Blood Vessel Models for Studying Trauma

Eugene V. Golanov

 

Part III: Clinical Challenges and Opportunities

20. Managing Edema and Intracranial Pressure in the Intensive Care Unit

Brian Cummings, Phoebe H. Yager, Sarah A. Murphy, Brian Kalish, Chetan Bhupali, Rebecca Bell, Zenab Mansoor, Natan Noviski, and Michael J. Whalen

 

21. Surgical Management of Traumatic Brain Edema

Takeshi Maeda, Tatsuro Kawamata, Atsuo Yoshino, Yoichi Katayama

 

22. Optimizing Hemodynamics in the Clinical Setting

Jose Alberto Toranzo and Claudia S. Robertson,

 

23. Cerebrovascular Autoregulation and Monitoring of Cerebrovascular Reactivity Philip M. Lewis, Marek Czosnyka, Piotr Smielewski, John D. Pickard

 

24. Cerebrovascular Responses after Pediatric Traumatic Brain Injury

Steven Shein, Nikki Ferguson, and Michael J. Bell

 

25. Subdural Hematoma in Non-Accidental Head Injury

Jennifer C. Munoz Pareja, Josephine Lok, Natan Noviski, Ann-Christine Duhaime

 

26. Blood Genomics after Brain Ischemia, Hemorrhage, and Trauma

Da Zhi Liu, Glen C Jickling, Boryana Stamova, Xinhua Zhan, Bradley P Ander and Frank R Sharp

 

27. Molecular Biomarkers in Neurocritical Care – The Next Frontier

Sherry H-Y Chou and MingMing Ning

 

 28. Bedside Monitoring of Vascular Mechanisms in CNS Trauma: The use of Near Infra-red Spectrpscopy (NIRS) and Transcranial Doppler (TCD)

Sarah Murphy, Brian Cummings, David Boas and Natan Noviski

 

29. In vivo MRI and MRS of Cerebrovascular Function following Traumatic Brain Injury

Chandler Sours, Rao P Gullapalli

 

Blurb

Vascular Mechanisms in CNS Trauma focuses on the vascular aspects of brain and spinal cord trauma.  Twenty nine chapters are arranged in three sections—Molecular Mechanisms; Experimental Models and Methods; and Clinical Challenges and Opportunities.  The first section addresses topics in the basic biology of brain and spinal cord trauma, ranging from the pathophysiology of cerebral endothelial cells and gliovascular interactions to the role of stem cells in neurovascular repair. The second section covers experimental methods in rodent and in large animal models of CNS injury, as well as the use of biomaterials and biomarkers in studying the mechanisms of tissue response. The third section deals with clinical issues in the monitoring and treatment of the patient with traumatic injury of the brain and spinal cord. Contributors to the book include an integrated mix of basic scientists and clinicians from diverse institutions. By presenting salient issues in CNS trauma from a vascular perspective, this book should make a unique contribution to the understanding of traumatic brain and spinal cord injury.