Vascular Mechanics and Pathology

ISBN-13: 9780387338163 / Angielski / Twarda / 2007 / 494 str.

Mano J. Thubrikar

Opis

Nowhere in the scientific progress has the schism in the knowledge been as striking as in the case of vascular mechanics and pathology. This joint subject would serve as a classic example of science developed in two different directions. It provided the motivation to put forth this book and establish a correlation between vascular mechanics and pathology. The book focuses on the artery and arterial diseases. The most fundamental functions of the artery are (1) to serve as a conduit of blood flow and (2) to serve as a container of blood pressure. The artery carries the blood to all organs of the body and it uses pressure to drive the blood through the tissue to provide nourishment. Hence, the artery is both a pipe and a pressure vessel. The artery pulsates about 103,000 times a day along with the beating heart. In a lifetime, the artery sustains cyclic pressure for about 3. 8 billion cycles. This obviously poses a significant challenge to the artery and therefore the artery must be endowed with special structure and properties to meet this challenge. In the event that additional challenges are imposed, such as high blood pressure, it would not be surprising that the artery could break down or become diseased. In the book, we examine the structure and properties of the artery and study the challenges imposed on it with a view to understand the survival of and the development of the diseases in the artery."

Spis treści

Atherosclerosis I.- Atherosclerosis II.- Structure and Mechanics of the Artery.- Pressure Vessel Principles.- Pressure Vessel Intersections.- Stress-Concentration in the Artery I.- Stress-Concentration in the Artery II.- Endothelial Cells and Low-Density Lipoproteins at the Branch.- Smooth Muscle Cells and Stretch.- Stress Reduction and Atherosclerosis Reduction.- The Vein Graft.- Anastomosis.- Anastomotic Aneurysms and Anastomotic Intimal Hyperplasia.- Intracranial Aneurysms.- Aortic Aneurysms.- Aortic Dissection.

O autorze

Dr. Mano J. Thubrikar has been with Edwards Lifesciences since December 2004. Previously, he was the Director of the Biomedical Engineering Program at the Heineman Medical Research Center at Carolinas Medical Center, Charlotte, NC. Dr. Thubrikar is a recipient of the Research Career Development Award from the National Institute of Health, the Certificate of Merit awarded by the New York Academy of Medicine, and the Minna-James Heineman Stiftung Research Award for Outstanding Research Achievements in the area of Life Sciences.

Blurb

Vascular Mechanics and Pathology

Mano J. Thubrikar, PhD, FAHA.

Opening new doors for interdisciplinary research, Vascular Mechanics and Pathology establishes a correlation between vascular mechanics and pathology that could lead to the reduction of vascular diseases, as well as the development of new treatments.

Vascular Mechanics and Pathology focuses on the artery and arterial diseases. As the fundamental functions of the artery are to serve as a conduit of blood flow and as a container of blood pressure, Vascular Mechanics and Pathology describes both the general principles and the occurrence of stress concentration at the pressure vessel junctions and examines the role of beta-blockers in the reduction of atherosclerosis and related complications. This cutting-edge work presents the use of veins as arterial grafts and discusses the role of vein valves in graft stenosis. Vascular Mechanics and Pathology illustrates aneurysm formation, growth, and rupture, using pressure vessel principles. This new work details the investigation of, amongst other topics, aortic dissection, showing for the first time that the aortic root mechanics plays a vital role in the development of this pathology.

Key topics:

• Atherosclerosis
• Structure and Mechanics of the Artery
• Pressure Vessel Principles
• Pressure Vessel Intersections
• Stress Concentration in the Artery
• Endothelial Cells and Low Density Lipoproteins at the Branch
• Smooth Muscle Cells and Stretch
• Stress Reduction and Atherosclerosis Reduction
• The Vein Graft
• Anastomosis
• Anastomotic Aneurysms and Anastomotic Intimal Hyperplasia
• Intracranial Aneurysms
• Aortic Aneurysms
• Aortic Dissection

Vascular Mechanics and Pathology is essential reading for cardiovascular researchers, surgeons, cardiologists, pathologists, radiologists, neurosurgeons, anatomists, students in biomedical engineering, and manufacturers of medical devices.

About the Author:

Dr. Mano J. Thubrikar has been with Edwards Lifesciences since December 2004. Previously, he was the Director of the Biomedical Engineering Program at the Heineman Medical Research Center at Carolinas Medical Center, Charlotte, NC. Dr. Thubrikar is a recipient of the Research Career Development Award from the National Institute of Health, the Certificate of Merit awarded by the New York Academy of Medicine, and the Minna-James Heineman Stiftung Research Award for Outstanding Research Achievements in the area of Life Sciences.