Vascular Dementia: Cerebrovascular Mechanisms and Clinical Management

ISBN-13: 9781588293664 / Angielski / Twarda / 2004 / 372 str.

Robert H. Paul; Brian R. Ott; Ronald Cohen

Opis

A multidisciplinary survey of our current understanding of the biological and clinical aspects of vascular disease. The authors describe its basic mechanisms, its clinical characteristics, its pharmacological management, and the use of neuroimaging methods to investigate it. The complex relationship between VaD and AD is also fully explored with chapters on how these processes interact and how one disease may lower the threshold for clinical expression of the other.

Recenzje

From the reviews:

"This book is an update on the link between cerebrovascular disease and dementia. ... The book has several strengths. ... The diagrams, images, and tables are generally thoughtful. ... Overall, Vascular Dementia is a valuable textbook. After reviewing it, I felt as if I had been brought up to date on a variety of topics related to the disorder ... . I would recommend the book to geriatricians, internists, and neurologists who care for elderly patients as well as to clinical researchers in geriatric neurology." (Carol F. Lippa, New England Journal of Medicine, June, 2005)

Spis treści

Part I. Introduction The Aging Population and the Relevance of Vascular Dementia Kelly L. Lange and Robert H. Paul Clinical Forms of Vascular Dementia Gustavo C. Román The Neuropathological Substrates of Vascular-Ischemic Dementia Kurt A. Jellinger Diagnosis of Vascular Dementia: Conceptual Challenges José G. Merino and Vladimir Hachinski Part II. Basic Mechanisms of Vascular Dementia Cerebral Hemodynamics in the Elderly Jorge M. Serrador, William P. Milberg, and Lewis A. Lipsitz The CADASIL Syndrome and Other Genetic Causes of Stroke and Vascular Dementia Stephen Salloway and Sophie Desbiens Estrogen, the Cerebrovascular System, and Dementia Sharon X. C. Yang and George A. Kuchel Effects of Hypertension in Young Adult and Middle-Aged Rhesus Monkeys Mark B. Moss and Elizabeth M. Jonak Part III. The Impact of Vascular Dementia on Cognitive, Psychiatric, and Daily Living The Cognitive Profile of Vascular Dementia Angela L. Jefferson, Adam M. Brickman, Mark S. Aloia, and Robert H. Paul Progression of Cognitive Impairments Associated With Cerebrovascular Disease Sally Stephens, Raj Kalaria, Rose Anne Kenny, and Clive Ballard Neuropsychiatric Correlates of Vascular Injury: Vascular Dementia and Related Neurobehavioral Syndromes Anand Kumar, Helen Lavretsky, and Ebrahim Haroon Functional Impairment in Vascular Dementia Patricia A. Boyle and Deborah Cahn-Weiner Part IV. Neuroimaging of Vascular Dementia Functional Brain Imaging of Cerebrovascular Disease Ronald Cohen, Lawrence Sweet, David F. Tate, and Marc Fisher Contributions of Subcortical Lacunar Infarcts to Cognitive Impairment in Older Persons Dan Mungas White Matter Hyperintensities and Cognition David J. Moser, Jason E. Kanz, and Kelly D.Garrett Poststroke Dementia: The Role of Strategic Infarcts Anelyssa D'Abreu and Brian R. Ott Part V. Interactions Between Vascular Dementia and Alzheimer's Disease Understanding Incidence and Prevalence Rates in Mixed Dementia John Gunstad and Jeffrey Browndyke Vascular Basement Membrane Abnormalities and Alzheimer's Disease Edward G. Stopa, Brian D. Zipser, and John E. Donahue Amyloid Beta and the Cerebral Vasculature Paula Grammas Cerebrovascular Disease and the Expression of Alzheimer's Disease Margaret M. Esiri and Zsuzsanna Nagy The Neuropsychological Differentiation Between Alzheimer's Disease and Subcortical Vascular Dementia David J. Libon, Stephen Scheinthal, Dana L. Penney, and Rod Swenson Part VI. Clinical Management of Vascular Dementia Pharmacological Treatment of Vascular Dementia Timo Erkinjuntti, Gustavo Román, Serge Gauthier, and Kenneth Rockwood Understanding and Managing Caregiver Burden in Cerebrovascular Disease Geoffrey Tremont, Jennifer Duncan Davis, and Mary Beth Spitznagel Quality of Life in Patients With Vascular Dementia Rebecca E. Ready and Brian R. Ott Approaches to Neuroprotection and Recovery Enhancement After Acute Stroke Marc Fisher and Magdy Selim Index

Blurb

With an aging population suffering from a high level of cardiac and cerebrovascular disease, it has become increasingly clear that the time may be ripe for a deeper understanding of vascular disease (VaD). In Vascular Dementia: Cerebrovascular Mechanisms and Clinical Management, a panel of multidisciplinary experts summarizes our current understanding of the biological and clinical aspects of the condition. The authors describe the basic mechanisms associated with aging and cerebrovascular disease that may play an important role in the development of VaD, and identify its impact on cognitive status, psychiatric health, and the ability of patients to complete the tasks of daily living. Additional chapters address the pharmacological management of vascular dementia and the use of neuroimaging methods to investigate it, with particular attention devoted to both functional and structural imaging techniques. The complex relationship between VaD and Alzheimer's disease (AD) is fully explored, with chapters on how these processes may interact and how one disease may lower the threshold for clinical expression of the other. The authors also consider the impact of VaD on the perceived quality of life of patients and caregivers, two issues rarely discussed in the scientific community.
Comprehensive and thoroughly up-to-date, Vascular Dementia: Cerebrovascular Mechanisms and Clinical Management offers both clinicians and basic scientists a wide ranging account of this rapidly developing field, explores the direction of future VaD studies, and authoritatively describes today's optimal therapeutic approaches.