Uveal Melanoma: A Model for Exploring Fundamental Cancer Biology

ISBN-13: 9789026519628 / Angielski / Twarda / 2004 / 272 str.

Martine J. Jager; Martine Jager

Opis

Uveal melanoma is the most common intraocular malignancy in adults, yet little is known about the factors that predispose patients to develop the disease. However, the availability of several uveal melanoma cell lines has fostered novel in vitro and in vivo studies that have added to our knowledge about the immunology, genetics, and molecular biology of uveal melanoma, revealing, for instance, that that uveal melanoma and cutaneous melanoma are remarkably different diseases.
Presenting this important research into the area, Uveal Melanoma summarizes developments regarding the biology and metastasis of the disease, and provides insight into the pathobiology of this type of melanoma, as well as a discussion of the necessary expansion of treatment options - thus shedding new light on what is undoubtedly a highly significant area of study.

Spis treści

1. Prognostic Indicators in Choroidal and Ciliary Body Melanoma Teemu Mäkitie, Martine J. Jager and Tero Kivelä 2. Oncogenes and Tumor Suppressor Genes in Uveal Melanoma J. William Harbour 3. Uveal Nevi versus Uveal Melanomas Jacob Pe'er 4. Genetic Predisposition in Uveal Melanoma Arun D. Singh 5. CDKN2A (p16) and Uveal Melanoma Nelleke A. Gruis 6. Inheritance and p16 M.A. Blasi, P. Grammatico 7. The Relevance of Chromosome Abnormalities in Posterior Uveal Melanoma Karen Sisley, Nicole Naus 8. Molecular Cytogenetic Characterization of Ten Uveal Melanoma Cell Lines A.E. Director-Myska, J.S. White, I.W. McLean 9. Developing Mouse Bone as an in vitro Model to Study Angiogenesis Gabri van der Pluijm, Clemens Löwik, Martine Deckers 10. Uveal Melanoma and Angiogenesis Shelley Boyd 11. Extravascular Matrix Patterns in Uveal Melanoma: Histogenesis, Structure, and Molecular Regulation Robert Folberg, Jacob Pe'er, Andrew J. Maniotis 12. Fluid-Conducting Meshworks in Uveal Melanoma Ruud Clarijs, Dirk J. Ruiter, Robert M.W. deWaal 13. Microvessels and Macrophages in Choroidal and Ciliary Body Melanoma Päivi Toivonen, Teemu Mäkitie, Tero Kivelä 14. Clinical Relevance of PAS Patterns in Uveal Melanomas Rita Parys-Van Ginderdeuren 15. Frequency of Microcirculation Patterns in Human Choroidal Melanomas using Simultaneous Confocal Sodium- Fluorescein/Indocyanine Green Angiography A.J. Mueller, D.-U. Bartsch, U. Schaller, W.R. Freeman, A. Kampik 16. Immune Privilege and Intraocular Tumors Jerry Y. Niederkorn 17. Immunogenetics in Uveal Melanoma M.J. Jager, J.A.W. Metzelaar-Blok, H.M.H. Hurks 18. HLA Expression in Uveal Melanoma H. Monique, H. Hurks, Martine J. Jager 19. Cell Adhesion Molecules: a brief review of their structure and function. Their role in uveal melanoma Gerasimos Anastassiou 20. Chemotherapy of Uveal Melanoma Ian A. Cree, Federica DiNicolantonia, Michael H. Neale

O autorze

M J Jager, J Y Niederkorn; B. R. Ksander