Use of Natural Polysaccharides in Medical Textile Applications » książka
Use of Natural Polysaccharides in Medical Textile Applications
ISBN-13: 9783639046069 / Angielski / Miękka / 2008 / 140 str.
Polysaccharides are composed of many monosaccharide units that are joined one to the other by an acetal linkage to give a long chain. In this work two special polysaccharides have been used as candidates in medical textile applications: chitosan and ss-cyclodextrin. Chitosan has been used as a new finishing agent in medical textile application. Chitosan has been used also as antimicrobial coating agent in modern dentistry to treat denture stomatitis. ss-cyclodextrin (ss-CD) has been used in this thesis as a drug release candidate in pharmaceutical application. The very low aqueous solubility of both antifungal agents (econazole nitrate and ciclopirox olamine) does not allow the preparation of a concentrated stock solution. Therefore, complexation with ss-CD has been improved the aqueous solubilities of both drugs without modification of their original structures, and hence increase their bioavailability. The antimycotic influence of ss-cyclodextrin complexes against Candida albicans DSM 11225 and Candida krusei ATCC 6258, hence, the drug solubility has been measured using a new, rapid and novel method called laser nephelometry in microtiter plates."
Polysaccharides are composed of many monosaccharide units that are joined one to the other by an acetal linkage to give a long chain. In this work two special polysaccharides have been used as candidates in medical textile applications: chitosan and ß-cyclodextrin. Chitosan has been used as a new finishing agent in medical textile application. Chitosan has been used also as antimicrobial coating agent in modern dentistry to treat denture stomatitis. ß-cyclodextrin (ß-CD) has been used in this thesis as a drug release candidate in pharmaceutical application. The very low aqueous solubility of both antifungal agents (econazole nitrate and ciclopirox olamine) does not allow the preparation of a concentrated stock solution. Therefore, complexation with ß-CD has been improved the aqueous solubilities of both drugs without modification of their original structures,and hence increase their bioavailability. The antimycotic influence of ß-cyclodextrin complexes against Candida albicans DSM 11225 and Candida krusei ATCC 6258, hence, the drug solubility has been measured using a new, rapid and novel method called laser nephelometry in microtiter plates.
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