Uric Acid Lithiasis: Workshop Tel Aviv 10.-12. Dezember 1980

ISBN-13: 9783798505940 / Angielski / Miękka / 1981 / 120 str.

O. Sperling; W. Vahlensieck

Opis

Kidney stones is a common and ancient disease. Yet, many questions concerning their etiology, treatment, and prevention are still open. The Harnstein-Symposien Bonn-Wien is an organization designed to bring together scientists from the various fields relevant to urolithiasis: medicine, urology, biochemistry, etc. In the framework of this organiza tion an International Workshop was held in Tel Aviv on December 10 and 11 1980 to discuss the various aspects of uric acid lithiasis. Uric acid stones have been known to mankind for thousands of years. Urate-contain ing stones were found in Egyptian mummies and in a three-thousand-year old mummy from Arizona. Evidently, with the constant increase in standard of living, associated with increased amount of purine intake, which we are facing in this century, the fre quency of uric acid lithiasis is on the increase. In the second half of this century, signi ficant progress has been made in the knowledge of the mechanisms of uric acid over production, as well as in the understanding of the etiology, prevention, and tretament of uric acid stones. As a result, uric acid lithiasis can be prevented and when present it can be treated well. Moreover most uric acid stones can be dissolved in vivo. This workshop included reviews from some of the leading authorities on the various aspects of uric acid metabolism in man: biochemistry, pathology, renal handling, nutri tion, etc., and these reviews and results of new studies are presented here."

Spis treści

Hyperuricemia-Epidemiology 1980.- Control of Purine Biosynthesis.- Nutrition and Uric Acid Metabolism: Plasma Level, Turnover, Excretion.- Mechanisms of Purine Overproduction in Man.- Uric Acid Hyperproduction and Isohydric Steady-state in Gouty Patients.- Juvenile Gout and Hyperuricosuria due to Chronic Compensated Hemolytic Syndrome.- Renal Excretion of Urate in Mammals.- Relation Between Urate Transport and Tubular Flow Rate in Rat and Man.- Renal Tubular Handling of Urate in Calcium Stone Formers with Hyperuricosuria or Renal Acidification Defects.- “Uric Acid” Stones in Children: Problems of Diagnosis and Treatment in a New Defect — Adenine Phosphoribosyltransferase Deficiency.- Complete Adenine Phosphoribosyltransferase Deficiency with 2,8-Dihydroxyadenine Stone Formation.- Idiopathic Uric Acid Lithiasis — Some Less Known Epidemiologie and Metabolic Findings.- The Contribution of Dietary Purines to Urinary Urate Excretion in Gouty and Renal Stone Patients.- Results of Examination in Renal Stone formers after Purine Load.- Latent Hyperuricemia and Hyperuricosuria — a Risk Factor for Stone Formation — Diagnosis with a Purine-Loading Test.- Laboratory Analysis of the Results of Treatment of Uric Acid Stones. “Zyloric U” — a New Insight (?).- The Action of a Benzbromarone-Citrate Preparation on Lithogenous and Inhibitory Substances.- Pathogenesis and Incidence of Calcium-containing and Pure Uric Acid Stones in Patients with Hyperuricemia and Hyperuricosuria.- Clinical Characteristics of the Calcium Stone Disease in Hyperuricosuria.- ?2-Microglobulin Excretion in Patients with Uric Acid Stones.