Unraveling the Exposome: A Practical View

ISBN-13: 9783319893204 / Angielski / Twarda / 2018 / 447 str.

Sonia Dagnino; Anthony Macherone

Opis

This volume presents a comprehensive overview of the science and application of the Exposome through seventeen chapters from leaders in the field. Section four provides an overview on statistical and computational techniques - including big data analysis - for characterizing the Exposome.

Spis treści

Part1. The utility of the Exposome Paradigm.- Chapter1. Using Exposomics to assess cumulative risks from multiple environmental stressors.- Chapter2. Sequencing the Public Health Exosome.- Chapter3. The US Military and the Exposome.- Chapter4. Framing Fetal and Early Life Exposome within Epidemiology.- Part2. Measuring the internal exposome.- Chapter5. Epigenetics and the exposome.- Chapter6. Metabonomics.- Chapter7. Transcriptomics within the exposome paradigm.- Part3. Measuring sources of exposure.- Chapter8. The food exposome.- Chapter9. The Dust Exposome.- Chapter10. From the Outside In; Integrating External Exposures into the Exposome Concept.- Part4. ata analysis for the exposome.- Chapter11. Statistical models to explore the exposome: from OMICs profiling to ‘mechanome’ characterization.- Chapter12. Data-driven Analytics and Informatics to Con-nect the Exposome with Phenotype in Larger Scale.- Part5. xposome characterization around the globe.-Chapter13. HERCULES: an academic center to support exposome research.- Chapter14. Exposomics: meet-in-the-middle and network perturbation.- Chapter15. Building an Early Life Exposome by Integrating Multiple Birth Cohorts: HELIX.- Chapter16. The HEALS project.- Part6. Conclusion.- Chapter17. Unravelling the exposome: conclusions and thoughts for the future.

O autorze

Dr. Sonia Dagnino is currently a Marie Sklodowska-Curie Research Fellow at the Epidemiology and Biostatistics Department at Imperial College London, School of Public Health. Dr. Sonia Dagnino's research is focused on the development of new methodologies for the understanding of the exposome and its implications for human health. Dr. Dagnino is actively engaged in several research projects on the exposome worldwide and has an extensive expertise in this field.

Dr. Macherone serves as a Senior Scientist with Agilent Technologies and a Visiting Professor at the Johns Hopkins School of Medicine. He is also on the faculty of P2i (Preconception 2 infancy) with a focus of providing “women and couples tools to improve their odds of healthy, full-term pregnancies, thus reducing the incidence of serious, chronic disorders among their children”. Dr. Macherone is an expert in exposomics and is actively engaged in several publicly or privately funded exposomics investigations. 

Blurb

This volume presents a comprehensive overview of the science and application of the Exposome through seventeen chapters from leaders in the field. At just over ten years since the term was coined by Christopher Wild in 2005, this is the first, field-defining volume to offer a holistic picture of the important and growing field of Exposomics. 

The term “Exposome” describes the sum of all exposures (not only chemical) that an individual can receive over a lifetime from both exogenous sources (environmental contaminants, food, lifestyle, drugs, air, etc.) and endogenous sources (metabolism, oxidative stress, lipid peroxidation, chemicals synthesized by the microbiome, etc.). The first section of this book contains chapters that discuss how the Exposome is defined and how the concept fits into the fields of public health and epidemiology. The second section provides an overview of techniques and methods to measure the human Exposome. The third section contains methods and applications for measuring the Exposome through external exposures. Section four provides an overview on statistical and computational techniques – including big data analysis - for characterizing the Exposome. Section five presents a global collection of case studies.