1. Discovery of insulin 2. Structure and properties of insulin 3. Biosynthesis of insulin 4. Biosynthesis, intracellular-trafficking, and exocytosis of insulin granules 5. Regulation of insulin secretion 6. Regulation of insulin secretion 7. Direct and indirect actions of insulin: role of insulin receptor, glucose transporters (GLUTs), and sodium-glucose linked transporters (SGLTs) 8. Metabolic and physiological effects of insulin 9. Etiopathogenesis of insulin resistance 10. Insulin resistance syndrome