"The book is written in an understandable, interesting manner suitable for a wide range of readers including undergraduate medical students and various health care professionals ... . Understanding Fever and Body Temperature: A Cross-disciplinary Approach to Clinical Practice is a well-written, concise, worth-reading book that provides valuable information about the regulation and assessment of body temperature and the pathophysiology and clinical implications of fever." (Mohamed Mohamed Tawfik, Anesthesia & Analgesia, Vol. 130 (6), June, 2020)
Table of Contents.
About the Authors.
Foreword.
Acknowledgements.
Chapter 1: Introduction to Understanding Fever and Body Temperature.
Chapter 2: History of Body Temperature.
Ancient times—An Imbalance in Bodily Fluids
Seventeenth Century—Accumulations of Waste Products and Fermentation
Eighteenth Century—Thermoregulation and the Natural Phases of Fever
Nineteenth Century—Medical Thermometers and "Fever Hospitals"
Twentieth Century—A Scientific Approach to Fever, Microorganisms, and Thermoregulation
Twenty-First Century—Interventions in Fever—Has Anything Changed?
Hypothermia
Reflections
References
Chapter 3: History of the Thermometer.
Thermoscopy
The Thermometer
The Fahrenheit Scale
The Centigrade Scale
The Kelvin Scale
Thermocouples
Tympanic Membrane Radiometry
Clinical Thermometry
The Clinical Thermometer
Non-Contact Temperature Measurement
Reflections
References
Chapter 4: Technical Accuracy.
Calibration
Traceability, Accreditation, ITS-90 and Standards
Clinical Thermometers
General Principles of Operation
Other Factors Affecting Measurement
Types of Thermometers
Reflections
References
Chapter 5: Thermoregulation of the Human Body.
Heat Production and Heat Loss
Heat Transfer
Radiation
Conduction
Convection
Evaporation
Physiology of Thermoregulation
Thermoreceptors
Set Point or Thermoeffector Threshold Zone
How to Maintain Normal Body Temperature
Cardio Vascular System
Sudomotor Control
Metabolism
Factors Affecting Body Temperature
Age and Gender Differences
Alterations in Body Temperature—Hyperthermia and Hypothermia
Reflections
General References
Specific References
Chapter 6: Physiological and Immunological Activity.
Physiological and Immunological Function of the Immune System
Inflammatory Activity Within Infections
Cells of the Immune System
Cells in the Innate Immune System
Cells in the Adaptive Immune System
Immunoglobulins
Cytokines
Pro-Inflammatory Cytokines
Cytonkines as REgulatros of Lymphocyte Activation, Growth, and Differentiation
Anti-Inflammatory Cytokines
Cytokines with Both Pro-Inflammation and Anti-Inflammation Activity
Immunological Activity During Pregnancy
The Competent System
Acute Phase Proteins
Pyrogenic Activity
Fever Phases
Reflections
General References
Specific References
Chapter 7: Assessment and Evaluation of Body Temperature.
Normal Body Temperature
Differences Between Individuals
Gender
Age
Differences within Individuals—Temperature Gradients Within the Body
Measurement of Body Temperature
Site of Measurement
The Rectal Site
The Oral Site
The Auxillary Site
The Ear Site
The Temporal Artery Site (Forehead)
Reflections
References
Chapter 8: Physiological and Inflammatory Activity in Various Conditions.
Hypersensitivity
Autoimmune Diseases
Autoinflammatory Diseases
Immunodeficiency
Malignancies
Metabolic and Endocrine Disorder
Diabetes
Atherosclerosis
Inflammation and Pain
Trauma, Neurodegenerative Disorders and Post-Operative Conditions Following Surgery
Inflammatory and Anti-Inflammatory Drugs
Reflections
General References
Specific References
Chapter 9: Clinical Implications.
The Adaptive Value of Elevated Body Temperature
Perceptions of Fever
Fever and Symptoms of Illness
Antipyresis
Antipyretics
Physical Anipyresis
Shivering
Fever in the Critically Ill
Fever in Frail, Elderly Individuals
Fever in Children
Antipyresis in Children
Febrile Seizures
Hyperthermia
Hypothermia
Therapeutic Hypothermia
Practical Guidelines when Assessing Body Temperature
Reflections
Specific References
Chapter 10: Conclusions.
Index.
Ewa Grodzinsky, Reg. BLS, PhD, is Associate Professor of Pharmaceutic Research at Linköping University in Linköping, Sweden
Märta Sund Levander, RNT, PhD, is Associate Professor of Nursing at Linköping University in Linköping, Sweden
This book uses problem-based learning (PBL) to give an interdisciplinary overview of the concept of fever. Sund-Levander and Grodzinsky approach fever in a broader perspective than is traditionally adopted, considering human thermal responses, the development of thermometry, thermoregulation as influenced by heat transfers and thermal gradients, and the relevance and implications of thermal measures as a diagnostic tool in clinical practice. The book is based on research in the fields of physiology, immunology, laboratory science, nursing care, and metrology, as well as a consideration of groundbreaking technological and scientific developments. To facilitate learning, the authors have included scenarios in the form of realistic situations from clinical practice, to be reflected on from an inter-professional perspective in clinical practice, and in advanced education of health care professionals, laboratory scientists, and technicians.