Unclassifiable Leukemias: Proceedings of a Symposium, Held on October 11 - 13, 1974 at the Institute of Cell Pathology, Hopital de Bicetre, Pari

ISBN-13: 9783540072423 / Angielski / Miękka / 1975 / 272 str.

M. Bessis; G. Brecher

Opis

Jean BERNARD * I should like to begin with an assumption and a paradox. The assumption is that leukemia is a disease of a stem cell characterized by pathologie alterations of that cell and its progeny. All present research and discussions are centered around the leukemic cell. So is this symposium, which would not take place except for our primary interest in the leukemic cell. This does not preclude, of course, consideration of other definitions and other approaches to the prOblem. By definition, then, the leukemic cells are abnormal cells and their metabolism and functions are presumed to be abnormal. Yet, the classification of the different types of leukemias is based upon the characteristics of normal cells. We talk of "lymphoblasts" and "myeloblasts" as predominant cell types in leukemia. This leads to a double paradox. In the first pi ace it is clearly illogical to classify abnormal cells by their resemblance to normal cells, since their very abnormality consists in not being normal. Yet, as a second paradox, the classifica ti on has had the happy consequence of ai ding us in the treatment and prognosis of leukemia for the past 25 years. A more detailed analysis shows that the consequence of this paradox are complex: while there exists a useful correlation between cellular types, treatment and prognosis, numerous problems and difficulties persist. The most serious of them concems the "unclassified leukemias" which are the reason for this reunion."

Spis treści

Section I: Present Practice of Classification, its Utility and Limitations.- Cytological Classification of Acute Leukemias. A Survey of 1400 Cases.- Classification of the Acute Leukemias.- Leukemic Lymphosarcomas: Respective Prognosis of the Three Types: Prolymphocytic, Lymphoblastic (or Lymphoblastoid) and Immunoblastic.- Search for Correlations between Cytological Types and Therapeutic Sensitivity of Acute Leukemias.- Answers to Submitted Questions.- Open Discussion of Section I.- Section II: New Techniques Used in Cytological Diagnosis.- Fluorescence Probe and Biochemical Characterization of Leukemic Cells.- Discussion.- Automated Cell Population Analysis.- Discussion.- The Use of B and T Membrane Markers in the Classification of Human Leukemias, with Special Reference to Acute Lymphoblastic Leukemia.- Discussion.- Volumetric Determinations of Blood Cells in Acute Lymphoblastic Leukemia.- Discussion.- Acute Leukemia Cytochemical Profile: Diagnostic and Clinical Implications.- Discussion.- B, T and “Null” Cell Leukemias. Electron Cytochemistry and Surface Morphology.- Discussion.- Giant Platelet Granules in Refractory Anemia (Preleukemia) and Myelomonocytic Leukemia: a Cell Marker?.- Discussion.- Inhibition of Time-dependent Enhancement of Amino Acid Transport by Leukemic Leukocytes: a Possible Index of the Sensitivity of Cells to Drugs.- Discussion.- Marrow Culture — a New Approach to Classification of Leukemias.- Discussion.- Cytogenetic Studies of Marrow and Peripheral Blood Granulocyte Colonies in Treated Chronic Myelogenous Leukemia (presented by G. Brecher) Discussion.- Cytogenetic Studies in Preleukemia: Studies before and after Transition to Acute Leukemia in 17 Subjects.- Discussion.- Correlated Cytogenetic and Ultrastructural Studies in Acute Leukemia (Abstract).- Discussion.- Section III: Pathophysiology of the Leukemic Cell.- Pathology of the Leukemic Cell or Reasons Why Some Leukemias are Unclassifiable.- Discussion.- Abnormal Neutrophils in Acute Myelogenous Leukemia: Identification of Subpopulations Based on Analysis of Azurophil and Specific Granules (Read by G. Brecher).- Significance of Cell Differentiation in Acute Myeloid Leukemia.- Discussion.- Different Cell Proliferation Models in Myeloblasts and Lymphoblastic Leukemia. Contribution of Cell Kinetics to the Classification of Acute Leukemias.- Discussion.- Clonal Evolution and Progression in Chronic Myeloid Leukemia.- Discussion.- Variations of the Proliferative Activity of Leukemic Myeloblasts Related to the Stage of the Disease.- Discussion.- Section IV: Summary and General Discussion.- Summing Up.- Summing Up.- On Classification of Leukemia.- General Discussion.