Tropical Diseases: From Molecule to Bedside

ISBN-13: 9781461349051 / Angielski / Miękka / 2012 / 386 str.

Sangkot Marzuki; Jan Verhoef; Harm Snippe

Opis

Tropical diseases remain a major global concern, not only because they affect a huge part of the world population, but also because of the growing global movement of people associated with employment, tourism, and war. Recent advances in molecular biology, epitomized by the genomic revolution, have brought new promises of powerful scientific approaches to fight such diseases. The WHO's Advisory Committee on Health Research recognizes this fact in its recommendation on Genomics and World Health and stresses the need for concerted efforts by scientists in the developed world, where most of the recent advances in life sciences have occurred, and those in the tropical, mostly less developed countries, where such diseases are endemic. Tropical Diseases: From Molecule to Bedside exemplifies such an effort. It covers a wide range of topics that reflect perspectives of northern and southern hemispheres. Fittingly, it defines tropical diseases in a broader-than-usual manner. For example, the book discusses traditional tropical medicine topics of infectious diseases and nutritional deficiencies. These diseases are common in the tropics, although some are associated more with poverty than with tropical living conditions. It also deals with genetic diseases and genomic issues that are truly associated with living in the tropics, e.g. the thalassemias. The book begins with several papers describing the vast human genetic diversity of Southeast Asia and its relationship to several genetic disorders. These papers illustrate the future direction of genomic activities in relation to disease susceptibility and resistance. The next sections deal with malaria and four specific viral and bacterial diseases of the tropics: hepatitis B and C, tuberculosis, and leprosy. These are then followed by a section on general bacterial infection. Two papers on nutrition complete the volume.
Proceedings of the second International Eijkman Symposium on Tropical Diseases: From Molecule to Bedside: In the Footsteps of Christiaan Eijkman, held September 2-6, 2001, in Bogor, Indonesia.

Spis treści

Genome and Disease:- Human Genome Diversity and Disease on the Island Southeast Asia; S. Marzuki, H. Sudoyo, H. Suryadi, I. Setianingsih, P. Pramoonjago. Mitochondrial Genome and Susceptibility to Diabetes Mellitus; H. Sudoyo, H. Suryadi, N. Sitorus, S. Soegondo, A. Pranoto, S. Marzuki. Ethnic and Geographical Distributions of CYP2C19 Alleles in the Populations of Southeast Asia; I. Yusuf, M.W. Djojosubroto, R. Ikawati, K. Lum, A. Kaneko, S. Marzuki. Alpha Thalassemia in Indonesia: Phenotypes and Molecular Defects; I. Setianingsih, A. Harahap, I.M. Nainggolan. Pathophysiology and Treatment of Iron Overload in Thalassemia Patients in Tropical Countries; J.J.M. Marx. Malaria :- Malaria on Islands; A. Kaneko. Plasmodium falciparum; S. Hudson Keenihan, R. Gramzinksi, S. Ratiwayanto, H. Hadiputranto, W. Riberu, S. Soebianto, F. Rusjdy, D. Syafruddin, A. KartikasariDAGGER, M. DjojosubrotoDAGGER, I. Setianingsih, A. Harahap, Krisin, D. Fryauff, T. Richie, Y. Charoenvit, H.A. Marwoto, S. Kumar, S. Hoffman, S. Marzuki, K. Baird. Molecular Basis of Antimalarial Drug Resistance in Indonesia; D. Syafruddin, P.B.S. Asih, J.E. Siregar, E. Tjitra. Unique properties of respiratory chain in Plasmodium falciparum mitochondria; F. Mi-Ichi, S. Takeo, E. Takashima, T. Kobayashi, H.-S. Kim, Y. Wataya, A. Matsuda, M. Torii, T. Tsuboi, K. Kita. Performance of rapid malaria Pf antigen test for the diagnosis of malaria and false-reactivity with autoantibodies; J. Iqbal, N. Khalid, P. Ravjee Hira. Phenotypic Switching and var Gene Transcription in Plasmodium falciparum; R. Noviyanti, G.V. Brown. Hepatitis B:- Hepatitis B Virus Molecular Diversity in Indonesia; D. Handojo Muljono, S. Soemohardjo. Transmission Profile of Hepatitis B Virus Infection in the Batam Region, Indonesia; J. van Hattum, G.J. Boland, K.G.J.J. Jansen, A.S. Kleinpenning, T. van Bommel, A.M. van Loon, S.A. Abdurachman, H. Yusuf, A. Rulos-van den Berg, J.P.B. van den Berg. The Efficacy of a Two-Dose Hepatitis B Vaccination Scheme; G.J. Boland, T. van Bommel, A. Rulos-van den Berg, J.P.B. van den Berg, A.M. van Loon, J. van Hattum. New Options in the Treatment of Chronic Hepatitis; S. Soemohardjo. Hepatitis C:- Prevalence of Hepatitis C Virus Infection among Haemodialysis Patients in West Java, Indonesia; J.R. Saketi, G.J. Boland, A.M. van Loon, J. van Hattum, S.A Abdurachman, E. Sukandar. Molecular Diversity of Hepatitis C Virus in the Batam Region; G.J. Boland, N. Cnossen, T. van Bommel, A. Rulos-van den Berg, J.P.B. van den Berg, A.M. van Loon, J. van Hattum. New Treatment Options for Chronic Hepatitis C; H. van Soest, J. van Hattum. Tuberculosis:- Pro-Inflammatory Cytokine Response in Acute Infection; B. Alisjahbana, M.G. Netea, J.W.M. van der Meer. Innate Immunity to Mycobacterium tuberculosis; R. van Crevel, T.H.M. Ottenhoff, J.W.M. van der Meer. Interferon-&ggr; production in response to M. tuberculosis antigens in TB patients in Indonesia; Y.W. Subronto, K.E. van Meijgaarden, A. Geluk, S.M. Arend, T. Sunardi, K.L.M.C. Franken, B. Hisyam, R.R.P. de Vries, T.H.M. Ottenhoff. Immune Reactivation and Paradoxical Worsening in an HIV-Infected Tuberculosis Patient; W.C.M. de Lange. Leprosy:- Epidemiology of Leprosy; M. Hatta. Human Deficiencies in Type-1 Cytokine Receptors Reveal the Essential Role of Type-1 Cytokines in Immunity to Intracellular Bacteria; T.H.M. Ottenhoff, T. de Boer, J.T. van Di