Transplant International: Proceedings of the 7th Congress of the European Society for Organ Transplantation Vienna, October 3-7, 1995

ISBN-13: 9783540610243 / Angielski / Miękka / 1996 / 497 str.

F. Muhlbacher; F. Ma1/4hlbacher

Opis

This supplement to TRANSPLANT International contains a most recent update of clinical and experimental research in transplantation and experiences with all modern immunosuppressive drugs, presented at the 7th Congress of the European Society of Organ Transplantation in Vienna in October 1995. The book has relevant information on clinical transplantation of kidneys, livers, hearts and pancreases as well as basic research data of immunbiology and organ preservation. More than 80% of the contributions were generated by respected European research institutions and therefore the book provides a comprehensive overview of European activities in transplantation research.

Spis treści

Kidney.- Rat cytomegalovirus infection and chronic kidney allograft rejection.- Does delayed kidney graft function increase the risk of chronic rejection?.- Evaluation of the permissible mismatch concept.- The significant effect of HLA-DRB1 matching on acute rejection in kidney transplants.- Five-year results of renal transplantation in highly sensitized recipients.- Anticipation of highly sensitised renal patients’ immunoadsorption requirements by prescreening using protein A minicolumns.- Weak expression of blood type B antigen in kidney tissue and successful B-incompatible kidney transplantation without special treatments.- Outcome of renal graft recipients with hepatitis C virus infection.- Pharmacokinetics and immunodynamics of chimeric IL-2 receptor monoclonal antibody SDZ CHI 621 in renal allograft recipients.- Acute rejection relapses posttransplant: definition of risk group and evaluation of potent therapeutic regimens.- Steroid-resistance rejection in kidney-transplanted patients: is ATG treatment for three or ten days preferable?.- Randomized trial of misoprostol in patients with chronic renal transplant rejection.- Increased tenascin expression is an early feature of the development of transplant renal arteriopathy in humans.- Is kidney transplantation in sensitized recipients justified?.- Low-density lipoprotein oxidation is increased in kidney transplant recipients.- The anaphylatoxin C5a, new parameter in the diagnosis of renal allograft rejection.- A critical analysis of soluble interleukin-2 receptor levels in kidney allograft recipients.- Diagnostic value of urinary enzyme determination in renal transplantation.- Retroperitoneal placement of living related adult renal grafts in children less than 5 years of age — a feasible technique?.- Short-term outcome of kidney transplants from non-heart-beating donors after preservation by machine perfusion.- Transplantation of kidneys harvested from non-heart-beating donors: early and long-term results.- Effective surface cooling of the kidney during vascular anastomosis decreases the risk of delayed kidney function after transplantation.- Kidney transplantation to patients with congenital malformations of the distal urinary tract.- Liver.- Impact of enalapril on microvascular perfusion and leukocyte adherence in a model of rat liver transplantation assessed by in vivo microscopy.- Quantitative analysis of the microcirculation of xenogeneic haemoperfused rat livers by intravital microscopy.- Beneficial effects of prostaglandin E1on hemodynamic changes during liver transplantation in pigs.- Pharmacokinetics of intravenous adriamycin for anhepatic chemotherapy during liver transplantation.- Liver transplantation for hepatocellular carcinoma: prognostic factors associated long-term survival.- DNA flow cytometry in patients undergoing liver transplantation for hepatocellular carcinoma.- Clinical significance of recurrent primary biliary cirrhosis after liver transplantation.- Hepatic resuscitation after warm anoxia: one approach for increasing the donor pool for liver transplantation.- Cytokine pattern in patients with infections after liver transplantation.- Prediction of graft dysfunction by analysis of liver biopsies after cold storage.- Validation of endothelin (ET) immunoreactivity in human bile by HPLC. Comparison of biliary ET concentration in liver transplant recipients with values obtained during cholecystectomy.- First clinical realization of continuous monitoring of liver microcirculation after transplantation by thermodiffusion.- Two-year data from the European multicentre tacrolimus (FK 506) liver study.- Tumor recurrence after oLTX.- The importance of late infections for the long-term outcome after liver transplantation.- Living related liver transplantation in children with hypoxemia related to intrapulmonary shunting.- Growth and height in children after liver transplantation.- Indications for Tacrolimus anti-rejection therapy in liver allograft recipients.- Cytomegalovirus infection does not increase the risk of vanishing bile duct syndrome after liver transplantation.- Extension of the indication for living related liver transplantation from children to adults based on resolution of graft size mismatch in relation to tissue oxygenation and metabolic load: a case report.- Incidence and outcome of arterial complications after orthotopic liver transplantation.- Hepato-venous outflow complications following orthotopic liver transplantation with various techniques for hepato-venous reconstruction in adults and children.- Bile duct splintage in liver transplantation: is it necessary?.- Effect of pre-reperfusion portal venous blood flush on early liver transplant function.- How to estimate the size of the donor liver.- Is hepatitis C virus recurrence a risk factor for chronic liver allograft rej ection?.- Hepatitis C: indication for anti-viral therapy?.- Effectiveness of early a-interferon therapy for hepatitis C virus infection recurrence after liver transplantation.- Hepatitis C virus Genotypes and reinfection of the graft during long-term follow-up in 35 liver transplant recipients.- Famciclovir therapy for recurrent hepatitis B virus infection after liver transplantation.- Expression of adhesion molecules and their ligands in liver allografts during cytomegalovirus (CMV) infection and acute rejection.- Heart/Lung.- Arrhythmogenic mortality in heart-transplant candidates.- Cytomegalovirus infection accelerates obliterative bronchiolitis of rat tracheal allografts.- Difference in cytokine production in acute and chronic rejection of rat lung allografts.- Pravastatin prevents the progression of accelerated coronary artery disease after heart transplantation in a rabbit model.- HLA-DR matching reduces rejection rate in heart transplantation.- Phenotypic analysis of lymphocytes infiltrating human cardiac allografts during acute rejection and the development of graft vascular disease.- Patterns in donor-specific mRNA and protein production of Thl and Th2 cytokines by graft-infiltrating lymphocytes and PBMC after heart transplantation.- Relationship between CMV and graft rejection after heart transplantation.- Evoked epimyocardial electrogram for rejection diagnosis after heart transplantation.- Valve reconstruction or replacement for long-term biopsy-induced tricuspid regurgitation following heart transplantation.- Pancreas.- Use of FK 506 in pancreas transplantation.- Liposoluble antioxidants are not consumed in the pancreas after reperfusion in human simultaneous pancreas-kidney transplantation.- Small Bowel.- circumvention of natural killer cell and T-cell mediated allogeneic target killing with tacrolimus (FK 506) in small bowel transplantation related graft-vs-host disease.- Colon vs small bowel rejection after total bowel transplantation in a pig model.- In vivo depletion of NKR-P1 positive cells in the recipient prior to small bowel transplantation enhances graft-versus-host disease (GvHD) in the rat.- Changes in blood lymphocytes populations in experimental bowel allograft rejection.- Microsurgical reconstruction of the lymphatic and nerve system in small bowel transplantation: the rat model, first results.- Lung.- Chronic rejection in lung allografts: immunohistological analysis of fibrogenesis.- Clinical experience with retrograde lung preservation.- Bronchiolitis obliterans syndrome (BOS) following heart-lung transplantation.- Immunosuppression.- Predicting patients’ exposure to cyclosporin.- Mycophenolate mofetil in patients with acute renal failure: evidence of metabolite (MPAG) accumulation and removal by dialysis.- UK multicentre study to assess the safety and tolerability of Neoral in stable renal transplant patients.- Comparison of Sandimmun with a new cyclosporin derivative (IMM 125) in renal transplant patients with stable renal function.- Induction of alloantigen-specific hyporesponsiveness in vitro by n-butyrate: antagonistic effect of cyclosporin A.- Prolonged allograft survival by the inhibition of costimulatory CD2 signals but not by modulation of CD48 (CD2 ligand) in the rat.- A short-term combination therapy with cyclosporine and rapamycin or leflunomide induces long-term heart allograft survival in a strongly immunogenic strain combination in rats.- Effect of RS61443 in combination with leflunomide or FK506 on rat heart allograft survival.- Immunobiology.- Rat MHC class I peptidase are immunogenic.- Correlation between the intensity of cytomegalovirus infection and the amount of perivasculitis in aortic allografts.- Evidence that cyclosporin A prevents clinical cardiac allograft rejection by blocking both direct and indirect antigen presentation pathways.- Liver sinusoidal lymphocytes: their immune functions.- Determination of HLA-B7 T-cell epitopes.- HLA class I A and B typing in the clinical laboratory using DNA-based techniques.- Flow cytometric crossmatching in renal transplantation — outcome after five years.- Allograft tolerance by intrathymic donor splenocyte transfer: an age-dependent, species-specific phenomenon?.- Total lymphoid irradiation, without intrathymic injection of donor cells, induces indefinite acceptance of heart but not islet or skin allografts in rats.- Induction of specific inhibition of alloreativity in beagle dogs by intrathymic injection of donor splenocytes.- Xenotransplantation.- Expression of human decay accelerating factor (hDAF) in transgenic pigs regulates complement activation during ex vivo liver perfusion — immunopathological findings.- Long-duration xenogeneic extracorporeal pig liver perfusion with human blood.- The function of transgenic human DAF-expression porcine livers during hemoperfusion with human blood.- Costs of drugs used after renal transplantation.- Ethical aspects of using “marginal” kidneys for transplant.- Organ Procurement.- Donor heart quality control. Analysis of echocardiographic (EC) findings and patient outcome.- Is the use of marginal donors justified in liver transplantation? Analysis of results and proposal of modern criteria.- The impact of donor age on graft outcome after liver transplantation.- The anti-ischemic drugs defibrotide and oligotide analogously inhibit leukocyte-endothelial cell adhesion in vitro.- Reduction in nonparenchymal cell injury and vascular endothelial dysfunction after cold preservation of the liver by gaseous oxygen.- Influence of UW solution on in vitro platelet aggregability.- Why is liver preservation performed at 4 °C?.- Na-K/2C1 transporter inhibition for reduction of postischemic kidney failure tested in autologous reperfusion.- Minimal amounts of hyaluronidase in HTK or UW solution substantially improve the recovery of preserved hearts.- Synergistic effects of nafamostat mesilate rinse and Kupffer cell blockade for rat liver preservation.- Tissue hydration in kidneys during preservation: a relaxometric analysis of time-dependent differences between cortex and medulla.- Organ Procurement.- Changes in renal hemodynamics and physiology after normothermic ischemia in animals supplemented with eicosapentaenoic acid.- Donor organ procurement in the North Italy Transplant program (NITp) in 1994: the beginning of a promising trend?.- Regionalization of donor organ procurement: first experiences in southern Bavaria and results of a regional donor hospital survey.- Marginal donors for patients on regular waiting lists for liver transplantation.- Injury to hepatocytes and non-parenchymal cells during the preservation of human livers with UW or HTK solution: a determination of hepatocellular enzymes in the effluent perfusate for preoperative evaluation of the transplant quality.- Pharmacokinetics of rinse solutions at 4 ° Celsius.- Assessment of oxygen radicals during kidney transplantation effect of radical scavenger.- Tissue.- Clinical experience with cotransplantation of peripheral nerve and adrenal medulla in patients with Parkinson’s disease.- Comparative analysis of immunological reconstitution induced by vascularized bone marrow versus bone marrow cell transplantation.