Translational Methods for Multiple Sclerosis Research

ISBN-13: 9781071612156 / Angielski / Miękka / 2021

Opis

This volume explores the recent advances in the study of translational paths in central inflammation and focuses on ongoing pathophysiological processes and the transition between inflammatory stages and progressive states with neurodegeneration. Chapters cover topics such as pathophysiological hallmarks of neuroinflammation from tissue damage to reorganization; connecting studies of mouse models; and investigations of humans with multiple sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. 

Cutting-edge and practical, Translational Methods for Multiple Sclerosis Research is a valuable resource for researchers who want to learn more about this chronic ad progressive disease, and pave the way for new advancements. 

Spis treści

Preface…
Table of Contents…
Contributing Authors…

Part I Pathophysiological Fingerprints of MS and Related Neuroimmunological Disorders

1. Pathophysiological Bases of Autoimmune Initiated/Mediated Neurodegeneration
Hans Lassmann

2. Translational Animal Models for MS and Related Neuroimmunological Disorders
Felix M. Glaser and Tobias Ruck

3. White Matter Pathology
Angela Radetz and Sergiu Groppa

4. Pathophysiology of Grey Matter Affection in MS
Gabriel Gonzalez-Escamilla and Dumitru Ciolac

5. Translational Characterization of Glia Role in Multiple Sclerosis
Dumitru Ciolac, Stanislav Groppa, and Gabriel Gonzalez-Escamilla

6. Translational Value of CSF and Blood Markers of Autoimmunity and Neurodegeneration
Timo Uphaus and Stefan Bittner

Part II Animal Models of Neuroinflammation 

7. Spontaneous Mouse Models of Neuroinflammation
Shin-Young Na and Gurumoorthy Krishnamoorthy

8. Chronic Progressive Models
Maren Lindner, Ann-Katrin Fleck, and Luisa Klotz

9. Electrophysiological Measurements of Brain Network Characterization in Rodents
Manuela Cerina, Luca Fazio, and Sven G. Meuth

Part III Translation of Functional Domain Abnormalities from Human to Mice 

10. Translation of Functional Domain Abnormalities from Human to Mouse Motor System
Muthuraman Muthuraman, Dumitru Ciolac, and Venkata Chaitanya Chirumamilla

11. Characterization of the Somatosensory System
Carsten H. Wolters, Marios Antonakakis, Asad Khan, Maria Carla Piastra, and Johannes Vorwerk

12. Translational Research in Neuroimmunology: Cognition
Maren Person and Miriam Becke

13. Models for Assessing Anxiety and Depression in Multiple Sclerosis: From Mouse to Man
Erik Ellwardt and Dirk Luchtman

Part IV Exploring Translational Paths in MS with Brain Imaging: Small Animal to Human Imaging Tools 

14. Human Structural MRI
Menno M. Schoonheim

15. Human Functional MRI
Paolo Preziosa, Paola Valsasina, Massimo Filippi, and Maria A. Rocca

16. Functional Studies in Rodents
Lydia Wachsmuth and Cornelius Faber

17. Non-Invasive Electrophysiology
Matthias Grothe

Part V Translational View on Therapeutic Strategies 

18. Targeting Acute Inflammation
Felix Lüssi

19. Translational Aspects of Immunotherapeutic Targets in MS
Vinzenz Fleischer

20. Therapeutic Strategies to Potentially Cure Multiple Sclerosis: Insights into the Mechanisms of Autologous Hematopoietic Stem Cell Transplantation
Leonie Rolfes and Marc Pawlitzki

21. Symptomatic MS Therapy
Julia Krämer and Sven G. Meuth