Translational Cardiometabolic Genomic Medicine

ISBN-13: 9780127999616 / Angielski / Twarda / 2015 / 352 str.

Rodriguez-Oquendo, Annabelle

Opis

Translational Cardiometabolic Genomic Medicine, edited by Dr. Annabelle Rodriguez-Oquendo, is an important resource to postgraduate (medical, dental and graduate) students, postdoctoral fellows, basic scientists, and physician scientists seeking to understand and expand their knowledge base in the field of genomic medicine as it is applied to cardiometabolic diseases. This handbook integrates cutting-edge experimental approaches such as chromatin immunoprecipitation paired end tagging (CHIA-PET), to population studies such as the Multi-Ethnic Study of Atherosclerosis. It encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome to the use of molecular diagnostic testing in predicting increased risk of cardiovascular diseases. Where applicable, this reference also includes chapters related to therapeutic options specifically aligned to molecular targets.

• Provides comprehensive research on translational genomic medicine
• Explains state-of-the-art genome editing for stem cells and mouse models with significant relevance to human cardiometabolic disease
• Includes discussions on the functional effects of single nucleotide polymorphisms and cardiometabolic diseases, stratified by sex and race
• Encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome

Spis treści

1.  Overview of human genome and currently commercially available tests for genetic testing, especially related to cardiometabolic diseases.
2. Overview of genome wide association studies.
3. Overview of publicly available datasets related to genomic medicine that will become important resources for scientists (such as ENCODE).  An emphasis will be placed on how scientists can navigate these sites.
4. Overview of genome editing in animal models and cell lines.
5. Overview of experimental approaches such as CHIA-PET to better understand chromosomal structure and long range chromatin interactions.
6. Overview of transcriptome biology, including microRNA biology and lipid metabolism.
7. Genomic medicine and lipid metabolism: LDL targets.
8. Genomic medicine and lipid metabolism: HDL targets.
9. Genomic medicine and diabetes.
10. Genomic medicine and hypertension.
11. Genomic medicine and vascular dementia (including Alzheimers and stroke).
12. Summary of the translational aspects of the basic science of the human genome and its application to the future of medicine.