Transgenic and Knockout Models of Neuropsychiatric Disorders

ISBN-13: 9781617376078 / Angielski / Miękka / 2010 / 296 str.

Gene S. Fisch; Jonathan Flint

Opis

In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.

Recenzje

Aus den Rezensionen:

"... Das vorliegende Buch versucht, den aktuellen Stand einer faszinierenden Entwicklung festzuhalten, und beleuchtet durch Aufsätze von international anerkannten Autoren verschiedene Aspekte des Einsatzes von transgenen Tiermodellen bei neuropsychiatrischen Krankheitsbildern. Der erste einführende Teil des Buches gibt einen Überblick über Geschichte und die Untersuchung von Tiermodellen bei neuropsychiatrischen Fragestellungen. ... Insgesamt stellt dieses Buch eine überaus interessante und anregende Lektüre ... und könnte dabei wichtige Anregungen zur translationalen Umsetzung von Forschungsinhalten ... vermitteln."

(H. H. Jung, in: Schweizer Archiv für Neurologie und Psychiatrie, 2007, Vol. 158, Issue 2, S. 91)

 

 

Spis treści

Introduction and Overview Transgenic and Knockout Models of Psychiatric Disorders: Introduction, History, and Assessment Gene S. Fisch Transgenic Mouse Models and Human Psychiatric Disease Jonathan Flint Transgenic and Knockout Mouse Models: The Problem of Language Linda J. Hayes and Diana Delgado If Only They Could Talk: Genetic Mouse Models for Psychiatric Disorders Trevor Humby and Lawrence Wilkinson Transgenic and Knockout Models of Neurocognitive Dysfunction Spinocerebellar Ataxia Type 1: Lessons From Modeling a Movement Disease in Mice Harry T. Orr Mouse Models of Hereditary Mental Retardation Hans Welzl, Patrizia D'Adamo, David P. Wolfer, and Hans-Peter Lipp How Can Studies of Animals Help to Uncover the Roles of Genes Implicated in Human Speech and Language Disorders? Simon E. Fisher Animal Models of Autism: Proposed Behavioral Paradigms and Biological Studies Thomas Bourgeron, Stéphane Jamain, and Sylvie Granon Transgenic and Knockout Models of Neuropsychiatric Dysfunction Genetic Mouse Models of Psychiatric Disorders: Advantages, Limitations, and Challenges Joseph A. Gogos and Maria Karayiorgou Animal Models of Psychosis Stephen I. Deutsch, Katrice Long, Richard B. Rosse, Yousef Tizabi, Ronit Weizman, Judy Eller, and John Mastropaolo Animal Models of Anxiety: The Ethological Perspective Robert Gerlai, Robert Blanchard, and Caroline Blanchard Modeling Human Anxiety and Depression in Mutant Mice Andrew Holmes and John F. Cryan Mutant Mouse Models of Bipolar Disorder: Are There Any? Anneloes Dirks, Lucianne Groenink, and Berend Olivier Index

Blurb

Neuroscientists are now establishing meaningful genotype-phenotype relationships for complex neurobehavioral and neuropsychiatric disorders and even creating animal models for these dysfunctions. These developments have made it imperative to know when such transgenic and knockout models are valid for the human disorders they represent. In Transgenic and Knockout Models of Neuropsychiatric Disorders, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, as well as speech disorders, and disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder. Timely introductory articles debate the alleged continuity of species of human and infrahuman behavior (Darwin), the utility of infrahuman animals in understanding human behavior and psychiatric disease, and the suitability of nonhuman models of complex neuropsychiatric dysfunctions involving language.
Comprehensive and systematic, Transgenic and Knockout Models of Neuropsychiatric Disorders offers a clear assessment of whether genetic abnormalities produced from infrahuman models manifest the neuropsychiatric disorders to which they correspond in humans and how best they may be used to carry out successful research today.