Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy

ISBN-13: 9781617377365 / Angielski / Miękka / 2010 / 786 str.

Sonia B. Jakowlew; C. -H Heldin

Opis

Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF- has been linked to several diseases. For instance, the effect ofTGF- on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF- has a very complicated role in cancer that is only beginning to be understood."

Recenzje

From the reviews:

"This volume ... provide readers with a detailed account of the role of TGF-beta in the development of various cancers in numerous organs. ... This will likely be of interest to those in the field as well as those who are new ... . will be of interest to researchers at all levels. The book will likely attract new researchers and students interested in becoming engaged in new frontiers of cancer therapy. ... This will be a great resource for researchers and clinicians ... ." (James P Luyendyk, Doody's Review Service, June, 2008)

Spis treści

Transforming Growth Factor-ß in Cancer Therapy Volume 2: Cancer Treatment and Therapy Sonia B. Jakowlew, Ph.D., Editor The Humana Press, Inc., Publisher TABLE OF CONTENTS In Memorium for Anita B. Roberts, PhD John M. McPherson* Preface Sonia B. Jakowlew* Foreward Carl-Henrick Heldin* Contributors Part I. Transforming Growth Factor-ß in Developing and Advanced Cancers 1 Transforming Growth Factor-ß Signaling in Pancreas Development and Pancreatic Cancer Sushil Rane*, Huei-Min Lin, Ji-Hyeon Lee, and Wan Jiao 2 Role of Transforming Growth Factor-ß (TGF-ß) in the Pathogenesis of Head and Neck Squamous Cell Carcinoma (HNSCC) Stephen M. Weber, Shi-Long Lu, Sophia Bernstein, and Xiao-Jing Wang* 3 TGF-ß, Smads and Cervical Cancer Devarajan Karunagaran* and Goodwin Jinesh 4 TGF-ß Signaling and Biglycan in Pancreatic Cancer Hendrik Ungefroren* 5 TGF-ß Signaling in Endometrial Cancer Dagmara Piestrzeniewicz-Ulanska*, David H. McGuinnes, and Grant R. Yeaman 6 TGF-ß Ligands, TGF-ß Receptors, and Lung Cancer Guiying Wang, Rongmei Zhang, Xiaohua Hu, Jiucun Wang, Lindsey J. Leach, and Zewei Luo* 7 Role of TGF-ß in Osteolytic Bone Metastases Laurent Bartholin* and Thesesa A. Guise 8 Hormonal Regulation of Transforming Growth Factor-beta in Breast Cancer Miriam Buck* and Cornelius Knabbe 9 TGF-ß Signaling in Esophageal Cancer Minoru Fukuchi*, Hiroyuki Kato, and Hiroyuki Kuwano 10 TGF-beta and HER2/ErbB2 and Breast Cancer Progression Natasa Todorovic-Rakovic* 11 TGF-beta dependent T Cell Regulation in Colitis and Colon Cancer Christoph Becker* and Markus F. Neurath 12 Role of Transforming Growth Factor-beta in the Kidney - Physiology and Pathology Elena Gagliardini and Ariela Benigni* 13 Perturbations of TGF-ß Signaling in Leukocytes as Driversof Leukemogenesis and Epithelial Tumorigenesis Lawrence A. Wolfraim* and John J. Letterio 14 Transforming Growth Factor-ß in Brain Functions and Dysfunctions Denis Vivien*, Karim Benchenane, and Carine Ali 15 Inhibition of TGF-ß Signaling in Multiple Myeloma and it's Bone Marrow Environment Hiroshi Yasui, Teru Hideshima, and Kenneth C. Anderson* 16 Key Roles of Smad3 in TGF-ß Responses in the Prostate Kyung Song and David Danielpour* 17 Smad Signaling in Leukemic Growth and Differentiation: Crosstalk Between Smad and Multiple Pathways Through Activation of the TGF-ß Type I Receptor Francis W. Ruscetti*, Salem Akel, Maria Birchenall-Roberts, Zhouhong Cao, and Anita Roberts Part II. Transforming Growth Factor-ß in Cancer Treatment and Therapy 18 High Throughput Screening of Protein Interaction Networks in the TGFß Interactome: Understanding the Signaling Mechanisms Driving Tumor Progression Miriam Barrios-Rodiles, Alicia Viloria-Petit, Kevin R. Brown, Igor Jurisica, and Jeffrey L. Wrana* 19 Tumor Suppressor and Pro-Progression Roles for TGF-ß in Breast Cancer Ethan Kohn* and Binwu Tang 20 Tumor Suppressors p53 and TGF-ß Converge to Regulate the Alpha-fetoprotein - Oncodevelopmental Tumor Marker Deepti S. Wilkinson and Michelle Craig Barton* 21 TGF-ß1: Roles in DNA Damage Responses Kumari L. Andarawewa, Julie Kirshner, Joni D. Mott, and Mary Helen Barcellos-Hoff* 22 The Rationale For and Effects of Targeting TGF-beta for Glioma Therapy Anita B. Hjelmeland* and Jeremy N. Rich 23 Tumor Suppressor Function of TGF-ß1 in T Cells Ramireddy Bommireddy* and Thomas Doetschman 24 Therapeutic Effects of Adenovirus-mediated Gene Transfer of TGF-ß Signal Antagonists on Undesirable Epithelial-mesenchymal Transition and Neovascularization Shizuka Saika* 25 Role of TGF-ß in Tumor Protection

Blurb

Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provides a compendium of findings about the role of transforming growth factor-ß (TGF-ß) in cancer treatment and therapy. The second volume, Cancer Treatment and Therapy, is divided into three parts. Part I examines transforming growth factor-ß in developing and advanced cancers. Part II details transforming growth factor-ß in cancer treatment and therapy. Part III includes an investigation into the development of inhibitors of transforming growth factor-ß signaling for therapy.

This volume’s companion, Basic and Clinical Biology, examines transforming growth factor-ß signaling in normal physiology, cancer pathobiology, normal and tumor biology, and inflammation and fibrosis. Together, Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor-ß in biology and cancer treatment.