Transforming Growth Factor-Beta in Cancer Therapy, Volume I: Basic and Clinical Biology

ISBN-13: 9781617377358 / Angielski / Miękka / 2010 / 735 str.

Sonia B. Jakowlew; M. B. Sporn

Opis

Transforming Growth Factor-jl in Cancer Therapy, Volume I: Basicand Clinical Biology The present volume brings together a wealth of information that is fundamental to understanding the roleofTGF- in the pathogenesis, prevention, and treatment of cancer. It is not even 25 years sinceTGF- was first isolated and characterized as a dimeric pep tide from both human and bovine sources (1-3), but the entire fieldofTGF- research has grown and expanded so that it is now a central theme in all of cell biology. There is almost no tissue or organ in the mammalian body in whichTGF- does not playa central role in embryonic differentiation or in adult function, and furthermore, malfunction of the normal physiologyofTGF- can have disastrous consequences in almost all ofthese sites. Therefore, the present comprehensive review of so many aspects ofTGF- function is a most welcome attempt to bring together a huge body of experimental data that is of the utmost importance in the field of oncology."

Recenzje

From the reviews:

"This volume provides a comprehensive review of TGF-beta regulation, signaling, and cellular function in both normal and tumor biology. ... will be of use to individuals interested in the role of TGF-beta in the development of cancer and fibrosis. This will likely benefit readers interested in TGF-beta in the pathogenesis of disease ... . also be a resource for those interested in the complex intracellular signaling cascades elicited by TGF-beta in normal and altered cells." (James P Luyendyk, Doody's Review Service, May, 2008)

Spis treści

Transforming Growth Factor-ß in Cancer Therapy Volume 1: Basic and Clinical Biology Sonia B. Jakowlew, Ph.D., Editor The Humana Press, Inc., Publisher TABLE OF CONTENTS In Memorium for Anita B. Roberts, PhD John M. McPherson* Preface Sonia B. Jakowlew* Foreward Michael B. Sporn* Contributors Part I. Basic Concepts of TGF-ß Signaling in Normal Physiology and Cancer Pathobiology 1 Component Hardware for Transforming Growth Factor-ß Signal Transduction: TGF-ß Ligands, TGF-ß Receptors, and Smads Sonia B. Jakowlew* 2 TGF-ß Signaling in Homeostasis and Cancer Joan Seoane* 3 TGF-ß Availability: Latent TGF-ß and Latent TGF-ß Binding Proteins Vesna Todorovic* and Daniel B. Rifkin 4 Biological Functions of Latent TGF-ß Binding Proteins and Activation of TGF-ß Marko Hyytiäanen*, Katri Koli, and Jorma Keski-Oja 5 Regulators of Smad2/3 Transcription and Phosphorylation Azeddine Atfi* and Marie-Francoise Bourgeade 6 Interaction of Smad4 and Embryonic Liver Fodrin (ELF)-ß-spectrin in Hyperplasia, Neoplasia, and Tumor Progression Sang Soo Kim, Charles Shuman, and Lopa Mishra* 7 Regulation of Smad Activity by Phosphorylation Fang Liu* 8 Nuclear Targeting of TGF-ß-activated Smads in Normal and Tumor Biology Lan Xu* 9 Ski, Sno and Akt as Negative Regulators of Smad Activity: Balancing Cell Death and Cell Survival Erwan Le Scolan and Kunxin Luo* 10 Smurfs in TGF-ß Signaling and Regulation of Bone Homeostasis and Cancer Ying E. Zhang* and Motozo Yamashita 11 Involvement of KM23 Dynein Light Chains in TGF-ß Signaling Qunyan Jin, Guofeng Gao, and Kathleen M. Mulder* 12 TGF-ß Signaling in Fibroblastic Cells and Oncogenes Neil A. Bhowmick* 13 Mechanisms of TGF-ß-induced Apoptosis in Cancer Cells Tae-Aug Kim* and Seong-Jin Kim 14 Mechanisms of Cell CycleRegulation by TGF-ß Disabled in Cancer Leslie I. Gold* and Jon Lecanda 15 Proteasome in the Control of TGF-ß Signaling During Development and Cancer Arja Band and Marikki Laiho* 16 TGF-ß and Smad Signaling in Transcriptome Reprogramming During Epithelial to Mesenchymal Transition Sylvie Thuault, Ulrich Valcourt, Marcin Kowanetz, and Aristidis Moustakas* 17 Functional Interaction between MMPs and TGF-ß in Normal and Tumor Tissue Christina H. Stuelten*, Anita B. Roberts, and William G. Stetler-Stevenson 18 Cooperation Between TGF-ß and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function Irwin M. Liu, Steven H. Schilling, and Xiao-Fan Wang* 19 Interaction of Oncogenic Ras and TGF-ß1 Signaling in Cancer: Lessons from the Multistage Skin Carcinogenesis Model Adam Glick*, Dong-Soon Bae, Xin Liu, and Kinnimulki Vijayachandra Part II. TGF-ß Superfamily Members in Normal and Tumor Biology 20 Proteomics Analysis of TGFß Superfamily Members Serhiy Souchelnytskyi* 21 Mullerian Inhibiting Substance: A Potential Nontoxic, Naturally Occurring Therapeutic Agent for Certain Human Cancers David T. MacLaughlin* and Patricia K. Donahoe 22 Activins, Inhibins and Bone Morphogenetic Proteins as Modulators of Prostate Cancer Progression Tetsu Hayashida, Vandana Gupta, Sam Thiagalinam, and Shyamala Maheswaran* 23 Bone Morphogenic Proteins and Angiogenesis in Developing Tumors George Berberian, Deepak Malhotra, and John E. Langenfeld* 24 Histone Methyltransferase and Smad Interactions in BMP Signaling Jennifer E. Leader, M. Pilar Frontelo, and Robert J. Lechleider* 25 Endoglin (CD105): A Strong Candidate for Immunologic Targeting of Tumor Neovasculature in Human Malignancies Ester Fonsatti and Michelle Maio* 26 Activins and Inhibins in Cancer Progression Gail P. Risbridger* and

Blurb

Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide a compendium of findings about the role of transforming growth factor-ß (TGF-ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. Part I presents basic concepts of transforming growth factor-ß signaling in normal physiology and cancer pathobiology. Part II investigates transforming growth factor-ß superfamily members in normal and tumor biology. Part III details transforming growth factor-ß in inflammation and fibrosis.

This volume’s companion, Cancer Treatment and Therapy, examines transforming growth factor-ß in several developing and advanced cancers and discusses methods of treatment and therapy. Together, Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor-ß in biology and cancer treatment.