Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies

ISBN-13: 9781439805091 / Angielski / Twarda / 2011 / 309 str.

Ajay K. Banga

Opis

Skin, once thought to be an impenetrable barrier, is an extremely active organ capable of interacting with its environment. Advancements in science combined with the need for diverse drug delivery modalities have introduced a variety of transdermal and intradermal products for existing drugs at a fraction of the cost of new drug development. Commercialization of transdermal drug delivery requires technology from many disciplines beyond pharmaceutical sciences, such as polymer chemistry, adhesion sciences, mass transport, web film coating, printing, and medical technology.

A comprehensive discussion of these technologies and practices, Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies covers:

• Commercial development of devices and products based on transdermal physical enhancement technologies
• Selecting optimal enhancement technology for a specific drug molecule using case studies
• Physicochemical properties and practical commercial considerations related to cost, unmet clinical needs, marketing, or intellectual property protection
• Technologies such as microneedles, iontophoresis, electroporation, and sonophoresis, with examples for delivery of small molecules, cosmeceuticals, proteins, and vaccines
• Practical information on experimental procedures and challenges related to skin irritation and safety issues

Up-to-date and accessible to researchers and industry experts, this book provides a comprehensive discussion of the physical approaches and practical considerations for the laboratory and marketplace.

Spis treści

Percutaneous Absorption and Enhancement Strategies. Experimental Methods and Tools for Transdermal Delivery by Physical Enhancement Methods. Microporation-Mediated Transdermal Drug Delivery. Iontophoretic Intradermal and Transdermal Drug Delivery. Skin Electroporation and Its Applications. Sonophoresis for Intradermal and Transdermal Drug Delivery. How to Go about Selecting the Optimal Enhancement Method for Transdermal Delivery of a Specific Drug Molecule: Case Studies. Transdermal Delivery of Peptides and Proteins. Transcutaneous Immunization via Physical Methods. Commercial Development of Devices and Products for Transdermal Physical Enhancement Technologies.

O autorze

Dr. Ajay K. Banga is Professor and Department Chair in the Department of Pharmaceutical Sciences at the College of Pharmacy and Health Sciences, Mercer University, Atlanta, Georgia. He also holds an Endowed Chair in transdermal delivery systems. His research expertise is in non-traditional approaches for transdermal drug delivery, especially for water soluble drugs including small conventional molecules and macromolecules. Dr. Banga has a Ph.D. in pharmaceutics from Rutgers University, New Jersey.

Dr. Banga has over 220 publications and scientific abstracts to his credit. His laboratory is funded by several start up and leading pharmaceutical companies. Dr. Banga currently serves on the Editorial Board of 7 journals, as Associate Editor for one journal, and has served as the Editor-in-Chief (2002-07) for a drug delivery journal. He has written two books in the areas of delivery of proteins and transdermal delivery. He has served on over 30 thesis/dissertation advisory committees and as a referee for over 28 journals. He is a Fellow of the American Association of Pharmaceutical Scientists.