Transcriptional Control of Lineage Differentiation in Immune Cells

ISBN-13: 9783319073941 / Angielski / Twarda / 2014 / 331 str.

Wilfried Ellmeier; Ichiro Taniuchi

Opis

Insights into the regulation of immune cell lineage differentiation and specification as well as into the control of lineage integrity, stability and plasticity are of fundamental importance to understanding innate and adaptive immune responses. In this volume, leading experts provide an up-to-date and comprehensive overview of recent advances in the transcriptional control mechanisms and transcription factor networks that regulate these processes in a variety of different immune cell lineages. The chapters cover the regulation of T versus B cell lineage choice, discuss early B cell development and pre-B cell leukemia prevention, address transcriptional control mechanisms during the differentiation, in regulatory T cells and iNKT cells, detail genomic switches in helper cell fate choice and plasticity and highlight the role of the BTB-zinc finger family of transcription factors in T cells. Moreover, the chapters discuss transcriptional networks in DCs, NK cells and in innate lymphoid cells. Together, the reviews illustrate key transcriptional control mechanisms that regulate the development and function of immune cells and demonstrate the impressive advances made over the last decade.

Spis treści

Genetic and epigenetic control of early lymphocyte development

Tomokatsu Ikawa

 

The role of BTB-zinc finger transcription factors during T cell development and in the regulation of T cell-mediated immunity

Wilfried Ellmeier and Ichiro Taniuchi

 

Transcriptional control of the development and function of Vα14i NKT cells

Isaac Engel and Mitchell Kronenberg

 

Transcriptional Control of Regulatory T cells

Michael Delacher, Lisa Schreiber, David D. Richards, Carla Farah, Markus Feuerer, Jochen Huehn

 

Transcriptional regulatory networks for CD4 T cell differentiation

Darah Christie and Jinfang Zhu

 

Transcriptional control of NK cell differentiation and function

Victoria Male and Hugh J.M. Brady

 

Transcriptional control of pre-B cell development and leukemia prevention

Swee Heng Milon Pang, Sebastian Carotta and Stephen L Nutt

 

Transcription factors controlling innate lymphoid cell fate decisions

Christoph S.N. Klose and Andreas Diefenbach

 

Transcriptional control of dendritic cell differentiation

Izumi Sasaki, Tsuneyasu Kaisho

 

Helper T cell plasticity: Impact of Extrinsic and Intrinsic Signals On Transcriptomes and Epigenomes

Michael Bonelli, Han-Yu Shih, Kiyoshi Hirahara, Kentner Singelton, Arian Laurence, Amanda Poholek, Tim Hand, Yohei Mikami, Golnaz Vahedi, Yuka Kanno and John J. O’Shea

O autorze

Wilfried Ellmeier, PhD., is Professor of Immunology at the Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology Medical University of Vienna, Austria. Taniuchi Ichiro, M.D. PhD. Professor is Group Director of the Laboratory for Transcriptional Regulation RIKEN Research Center for Allergy and Immunology (RCAI), Japan.

Blurb

Insights into the regulation of immune cell lineage differentiation and specification as well as into the control of lineage integrity, stability and plasticity are of fundamental importance to understanding innate and adaptive immune responses. In this volume, leading experts provide an up-to-date and comprehensive overview of recent advances in the transcriptional control mechanisms and transcription factor networks that regulate these processes in a variety of different immune cell lineages. The chapters cover the regulation of T versus B cell lineage choice, discuss early B cell development and pre-B cell leukemia prevention, address transcriptional control mechanisms during Th differentiation, in regulatory T cells and iNKT cells, detail genomic switches in helper cell fate choice and plasticity, and highlight the role of the BTB-zinc finger family of transcription factors in T cells. Moreover, the chapters discuss transcriptional networks in DCs, NK cells and in innate lymphoid cells. Together, the reviews illustrate key transcriptional control mechanisms that regulate the development and function of immune cells and demonstrate the impressive advances made over the last decade.