Tracing Disease Genes in Non-syndromic Clefts of Orofacial region » książka
Tracing Disease Genes in Non-syndromic Clefts of Orofacial region
ISBN-13: 9783659688621 / Angielski / Miękka / 2015 / 68 str.
Orofacial clefts are major human birth defects with complex etiology. Previous studies have proposed Transforming growth factor - beta 3 (TGF-B3) gene as one of the important genes in which polymorphisms may contribute to nonsyndromic cleft lip and palate, however none of the studies included Indian population. The HLA Human leucocyte antigen] loci are the most polymorphic human proteins, and by virtue of their extreme polymorphism ensure that few individuals are identical. Hence HLA typing can be used to identify a subset of population who are at an increased risk of developing or inheriting a particular disease or anomaly. Studies pertaining to the relationship of HLA haplotype and cleft lip and palate are very few and none of these includes Indian patients. This study is a pioneering step towards establishing an association of HLA class I genes and TGFB3 gene with cleft lip and palate in patients of Indian origin.
Orofacial clefts are major human birth defects with complex etiology. Previous studies have proposed Transforming growth factor - beta 3 (TGF-B3) gene as one of the important genes in which polymorphisms may contribute to nonsyndromic cleft lip and palate, however none of the studies included Indian population. The HLA [Human leucocyte antigen] loci are the most polymorphic human proteins, and by virtue of their extreme polymorphism ensure that few individuals are identical. Hence HLA typing can be used to identify a subset of population who are at an increased risk of developing or inheriting a particular disease or anomaly. Studies pertaining to the relationship of HLA haplotype and cleft lip and palate are very few and none of these includes Indian patients. This study is a pioneering step towards establishing an association of HLA class I genes and TGFB3 gene with cleft lip and palate in patients of Indian origin.
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