Trace Elements in Brain Health and Diseases

ISBN-13: 9789819915125 / Angielski / Twarda / 2023

Opis

This book reviews the role of trace elements in brain development, function, metabolism, and neurodegenerative disorders. It explores the molecular mechanisms of the effects of trace elements on  metabolic pathways, mitochondrial nutrients, neurodegeneration, Central Nervous System (CNS) disorders, cell signaling, and neuronal functions. The book also discusses transport mechanisms of trace elements within CNS and their impact on neurotransmitter biology. Further, it examines the deleterious effects due to dyshomeostasis of trace elements in the central nervous system (CNS), resulting in damage to neurons and glial cells through the generation of reactive oxygen species and oxidative stress turn leading to neurodegeneration and neurological dysfunction. The book also explores the putative role of trace element deficiency in psychiatric disorders, including depression, and the imbalance of trace elements on neuronal genomic stability.

Spis treści

Chapter 1_Overview of Trace Elements. –Chapter 2_Trace elements and brain development. –Chapter 3_Trace elements and brain function. –Chapter 4_Trace elements and oxidative stress. –Chapter 5_Trace elements and neurotransmitters. –Chapter 6_Homeostasis of trace elements in the brain. –Chapter 7_ Putative role of trace elements deficiency in psychiatric disorders including depression. –Chapter 8_Trace elements and neuro-developmental disorders. –Chapter 9_Trace elements and Parkinson's disease. –Chapter 10_Trace elements and Alzheimer's disease. –Chapter 11_Trace elements and multiple sclerosis. –Chapter 12_Trace elements and epilepsy. –Chapter 13_Trace elements and sleep disorders. –Chapter 14_Trace elements and Subarachnoid Hemorrhagic Stroke. –Chapter 15_Trace elements and Brain Cancer. –Chapter 16_Impact of excess/deficient trace elements on neuronal genomic stability. –Chapter 17_Trace elements in OMICS era. –Chapter 18_Blood markers of oxidative stress in patients with ALS.

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O autorze

Dr. Wael Mohamed Yousef Mohamed is a Clinical Pharmacologist, Neuroscientist and Psychiatrist. Dr. Mohamed got his PhD from PSU, USA and is currently working as an Assistant Professor in IIUM Medical School, Malaysia. He published over 70 peer-reviewed papers related to Neuroscience/Psychiatry. He is an editor of the Frontiers in Neurology, and PLOS-ONE Journals Additionally, he has edited few books in neuroscience field with Springer and Cambridge. He has received many research grants from national and international organizations namely, IBRO, ISN, MJF, STDF, FRGS and INDO-ASEAN.

Professor Rajat Sandhir has received his M.Sc and Ph.D. degree in Biochemistry from the Postgraduate Institute of Medical Education and Research, Chandigarh, India. Presently he is working as a Professor at the Department of Biochemistry, Panjab University. His research interests are focused to understand the biochemical and molecular mechanisms involved in development of neurodegenerative conditions like metabolic encephalopathies, dementia's and motor disorders with a particular interest to investigate the role of oxidative stress, mitochondrial dysfunctions and alterations in permeability of Blood-Brain-Barrier. In addition, his interest is also to identify neuroprotective strategies that ameliorate neurodegenerative conditions. His group is also interested in understanding role of trace elements in brain particularly selenium during early development. He has over 200 research articles to his credit and has been on the editorial board of several international journals. He is also Fellow of Indian Academy of Neurosciences and Indian Association of Biomedical Scientists (IABMS). He has recently been awarded KT Shetty Memorial Oration 2021 by the Indian Academy of Neurosciences. He has been listed among the World 2% Scientists for the year 2020 released now by the Stanford researchers from Panjab University.