Toxicologic Pathology for Non-Pathologists

ISBN-13: 9781493997763 / Angielski / Twarda / 2019 / 919 str.

Thomas J. Steinbach; Daniel J. Patrick; Mary Ellen Cosenza

Spis treści

1. Introduction to Toxicologic Pathology

            George A. Parker

 

2. The Pathology Report, Peer Review, and Pathology Working Group

            Ted A. Birkebak and Peter C. Mann

 

3. Routine and Special Techniques in Toxicologic Pathology

            Pamela Blackshear, Erica Carroll, Sasmita Mishra, Matthew Renninger, and Arun Tatiparthi

 

4. Pathology of the Liver and Gallbladder

            Robert R. Maronpot and David E. Malarkey

 

5. Pathology of the Gastrointestinal Tract and Exocrine Pancreas

            Mark J. Hoenerhoff and Arun Kumar R. Pandiri

 

6. Pathology of the Urinary System

            Kendall S. Frazier

 

7. Pathology of the Nervous System

            Juliana S. Lee, Sarah D. Cramer, and Mark T. Butt

 

8. Pathology of the Cardiovascular System

            Joshua H. Decker, Radhakrishna Sura, and Paul W. Snyder

 

9. Pathology of the Respiratory System

            Jack R. Harkema and James G. Wagner

 

10. Pathology of the Lymphoid System

            Tracey L. Papenfuss, Marlon C. Rebelatto, and Brad Bolon

 

11. Pathology of the Male and Female Reproductive System and Mammary Gland

            Justin D. Vidal

 

12. Pathology of the Integumentary System

            Kelly L. Diegel

 

13. Pathology of the Endocrine System

            Brent E. Walling and Thomas J. Rosol

 

14. Pathology of Bone, Skeletal Muscle, and Tooth

            Stacey Fossey, D. Greg Hall, Andrew Suttie, Martin Guillot, and Aurore Varela

 

15. Pathology of the Eye

            Leandro B.C. Teixeira

 

16. Pathology of the Ear

            Kenneth A. Schafer

 

17. Principles of Toxicologic Clinical Pathology

            Adam Aulbach and Laura Cregar

 

18. Carcinogenicity

            Paul Howroyd

 

19. Pathology of Juvenile Animals

            Catherine A. Picut and Amera K. Remick

 

20. Non-Mammalian Laboratory Species: Fish, Frogs, and Beyond

            Shannon Wallace and Jeff Wolf

 

 

Appendix: Fundamental Pathology Terminology Based on the Standard for the Exchange of Nonclinical Data (SEND)

O autorze

Thomas J. Steinbach DVM, DACVP, DABT (Experimental Pathology Laboratories, Inc., Research Triangle Park, NC, USA) and Daniel J. Patrick DVM, DACVP, DABT (Charles River Laboratories, Inc., Mattawan, MI, USA) have worked for numerous years to help organize the successful "Pathology for Non-Pathologists" short course, created with the support of the American College of Toxicology (ACT) and Society of Toxicologic Pathology (STP), upon which this book is based. Mary Ellen Cosenza PhD, DABT, RAC, ATS (MEC Regulatory & Toxicology Consulting, LLC, Moorpark, CA, USA) was an inaugural committee member of this short course and remains a highly respected member of the community at large.

Blurb

This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances. 

Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.